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Biochimica et Biophysica Acta (BBA) - Protein Structure, 1978
Using isoelectric focusing, a fetal hemoglobin was found in the peripheral blood of C57BL/6 fetal mouse during the 14 to 20 days gestational period. In acid-urea polyacrylamide gel the pattern of this fetal hemoglobin was different from that of the adult hemoglobin.
Wu, N, Sikkema, D A, Zucker, R M
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Using isoelectric focusing, a fetal hemoglobin was found in the peripheral blood of C57BL/6 fetal mouse during the 14 to 20 days gestational period. In acid-urea polyacrylamide gel the pattern of this fetal hemoglobin was different from that of the adult hemoglobin.
Wu, N, Sikkema, D A, Zucker, R M
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5‐azacytidine and fetal hemoglobin
American Journal of Hematology, 1984AbstractThe evidence that 5‐azacytidine stimulates the production of Hb F and F cells in baboon and man is reviewed. The mechanism of this effect is not entirely clear, but 5‐azacytidine produces hypomethylation of the γ gene at certain sites, and gene expression and DNA hypomethylation are related phenomena in many other systems. Other mechanisms have
Joseph DeSimone, Paul Heller
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Fetal hemoglobin levels in adults
Blood Reviews, 1994The synthesis of fetal hemoglobin (HbF) is normally reduced to very low levels of less than 0.6% of the total hemoglobin in adults. The HbF is restricted to a sub-population of erythrocytes termed 'F-cells'; 85% of the normal adult population have 0.3% to 4.4% F-cells.
J. Rochette +3 more
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The Bohr effect of fetal hemoglobin
American Journal of Obstetrics and Gynecology, 1968Abstract The Bohr effect of solutions of hemoglobin A, F, and A-F was studied. Between pH 7.2 and pH 7.8 the calculated Bohr effect was φ = −0.48 for all three solutions. However, between pH 7.2 and pH 6.5 the Bohr effect of hemoglobin F was greater (φ = −0.51) than hemoglobin A (φ = −0.43).
Seymour L. Romney, Leon I. Mann
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Fetal hemoglobin as an index of maturity
American Journal of Obstetrics and Gynecology, 1959Abstract The percentage of fetal hemoglobin was determined in 200 samples of cord blood and an attempt was made to correlate this percentage with fetal age and weight. In the term group fetal hemoglobin varied from 55 to 95 per cent with an average of 73.3 per cent. The preterm group averaged 80.6 per cent with a range of 66 to 92 per cent, while the
Ralph A. Reis +5 more
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Fetal Hemoglobin Variants in Mice
Science, 1968Two strains of mice, DBA and C3H, have a fetal globin polypeptide chain which differs in electrophoretic mobility from the corresponding fetal chain of the C57B1 strain. Mice of the DBA and C3H strains also differ from those of the C57B1 in adult hemoglobin type. Results of backcrossing the (DBA × C57B1) hybrid to the C57B1 suggest that the fetal chain
Gilman, J G, Smithies, O
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The initiation of fetal hemoglobin biosynthesis
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979Biosynthesis of the alpha and beta chains of rabbit and human adult hemoglobin is initiated with a methionyl residue, which is removed during elongation of the peptide chain. To study the initiation of biosynthesis of the delta chain of human fetal hemoglobin, fresh placental blood was used for labeling experiments with radioactive amino acids. Labeled
Hitoshi Imanishi +2 more
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The heterogeneity of the fetal hemoglobin of the goat
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1969Abstract The heterogeneity of the goat fetal hemoglobin, which has been observed by measurements of the rate of denaturation in an alkaline medium, was reinvestigated. Analyses of the amino acid compositions of various peptides isolated from a tryptic digest of the γ chain failed to demonstrate a molecular heterogeneity.
H.R. Adams +2 more
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Fetal Hemoglobin in Diabetic Patients
Diabetes Care, 1994OBJECTIVE To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS A cross-sectional study was conducted. HbA1c.
Jorma Lahtela +2 more
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