Results 81 to 90 of about 826,759 (374)

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Blood, 2016
Overcoming the silencing of the fetal γ-globin gene has been a long-standing goal in the treatment of sickle cell disease (SCD). The major transcriptional enhancer of the β-globin locus, called the locus control region (LCR), dynamically interacts with ...
L. Breda, I. Motta, S. Lourenço, Chiara Gemmo, Wulan Deng, J. Rupon, O. Abdulmalik, D. Manwani, G. Blobel, S. Rivella   +9 more
semanticscholar   +1 more source

Imiquimod‐Loaded Phospholipid‐Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases

Advanced Healthcare Materials, EarlyView.
Imiquimod‐loaded nanoparticles (PFSUV‐IMQ) are found to decrease liver metastasis and liver tumor burden when administered intravenously. Flow cytometry, RNA‐seq and various experiments show that the anti‐tumor response is immune‐mediated by activating dendritic cells resulting in increased CD8 T cell infiltration and activity.
Vanessa Chan, Hsin‐Mei Lee, Haruka Takata, Sheng‐Liang Cheng, Yu‐Ting Yen, Lisa Pfeifer, Luke Rushton, Po‐Han Chao, Feng Zhao, Chun Yat Ong, Nojoud Al‐Fayez, Tatsuhiro Ishida, Yunching Chen, Shyh‐Dar Li   +13 more
wiley   +1 more source

A validated cellular biobank for β-thalassemia [PDF]

, 2016
Background: Cellular biobanking is a key resource for collaborative networks planning to use same cells in studies aimed at solving a variety of biological and biomedical issues. This approach is of great importance in studies on β-thalassemia, since the
BIANCHI, Nicoletta, BORGATTI, Monica, BREDA, Laura, BREVEGLIERI, Giulia, Chiavilli, Francesco, COSENZA, Lucia Carmela, FINOTTI, Alessia, GAMBARI, Roberto, GAMBERINI, MARIA RITA, LAMPRONTI, Ilaria, Manunza, Laura, Martis, Franca Rosa, Moi, Paolo, Rivella, Stefano, Satta, Stefania, ZUCCATO, Cristina   +15 more
core   +2 more sources

Genome-wide analysis of aberrantly expressed lncRNAs and miRNAs with associated co-expression and ceRNA networks in β-thalassemia and hereditary persistence of fetal hemoglobin

OncoTarget, 2017
The implications of lncRNAs regarding fetal hemoglobin (HbF) induction in hemoglobin disorders remain poorly understood. In this study, microarray analysis was performed to profile lncRNAs, miRNAs and mRNAs in individuals with hereditary persistence of ...
Ketong Lai, Siyuan Jia, Shanjuan Yu, Jianmin Luo, Yunyan He   +4 more
semanticscholar   +1 more source

Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy

Advanced Healthcare Materials, EarlyView.
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley   +1 more source

HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts. [PDF]

PLoS ONE, 2016
Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs (miRNAs) are highly regulated in erythroid cells during the fetal-to-adult developmental transition ...
Jaira F de Vasconcellos, Y Terry Lee, Colleen Byrnes, Laxminath Tumburu, Antoinette Rabel, Jeffery L Miller   +5 more
doaj   +1 more source

Conference scene : Golden Helix Pharmacogenomics Days : educational activities on pharmacogenomics and personalized medicine [PDF]

, 2012
The Golden Helix Pharmacogenomics Days are high-profile international educational scientific meetings discussing pharmacogenomics and personalized medicine.
Borg, Joseph J., Fenech, Anthony G., Grech, Godfrey, Patrinos, George P., Severino, Giovanni, Squassina, Alessio   +5 more
core   +2 more sources

Upconversion Nanoparticle‐Covalent Organic Framework Core–shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging

Advanced Materials, EarlyView.
Upconversion nanoparticle‐covalent organic framework core–shell particles provide enhanced contrast for optoacoustic imaging by leveraging the optical absorption of upconversion luminescence within the covalent organic framework matrix. Beyond their role as contrast agents, these particles enable customizable therapeutic agent loading and release, as ...
Dong Wook Kim, Paul Wrede, Andrés Rodríguez‐Camargo, Yi Chen, Nihal Olcay Dogan, Chaim Glück, Bettina V. Lotsch, Daniel Razansky, Metin Sitti   +8 more
wiley   +1 more source

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders

International Journal of Hematology-Oncology and Stem Cell Research, 2013
Objective: The use of fetal hemoglobin (HbF) inducer drugs is considered as a novel approach in treatment of β-hemoglobinopathies, especially β- thalassemia and sickle cell disease. HbF inducers including hydroxyurea, histone deacetylase (HDAC) inhibitor
Fatemeh Salari, Mohammad Shahjahani, Seyed Ahmad Hosseini, Ali Dehghani Fard, Kaveh Jaseb   +4 more
doaj   +2 more sources

Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans [PDF]

, 2002
We have developed a liquid chromatography/mass spectrometry (LC-MS/MS) assay to determine acrylamide in various body fluids. The assay also allows the reliable quantitation of acrylamide in food. In a total of 11 healthy male and female subjects, we were
Hofmann, A., Illauera, M., Kinzig-Schippers, M., Landersdorfer, C., Skott, A., Sorgel, F., Weissenbacher, R.   +6 more
core   +1 more source