Results 81 to 90 of about 821,341 (299)
Optimal villi density for maximal oxygen uptake in the human placenta
, 2015 We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry ...
Brownbill, P. +4 more
core +1 more source
Haematologica, 2011 The persistence of high fetal hemoglobin level in adults may ameliorate the clinical phenotype of beta-thalassemia and sickle cell anemia. Several genetic variants responsible for hereditary persistence of fetal hemoglobin, linked and not linked to the ...
Stefania Satta +9 more
doaj +1 more source
OncoTarget, 2017 The implications of lncRNAs regarding fetal hemoglobin (HbF) induction in hemoglobin disorders remain poorly understood. In this study, microarray analysis was performed to profile lncRNAs, miRNAs and mRNAs in individuals with hereditary persistence of ...
Ketong Lai +4 more
semanticscholar +1 more source
A validated cellular biobank for β-thalassemia [PDF]
, 2016 Background: Cellular biobanking is a key resource for collaborative networks planning to use same cells in studies aimed at solving a variety of biological and biomedical issues. This approach is of great importance in studies on β-thalassemia, since the
BIANCHI, Nicoletta +15 more
core +2 more sources
HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts. [PDF]
PLoS ONE, 2016 Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs (miRNAs) are highly regulated in erythroid cells during the fetal-to-adult developmental transition ...
Jaira F de Vasconcellos +5 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundPostpartum hemorrhage (PPH) is one of the leading causes of maternal mortality. Promptly recovering blood loss is critical for PPH. Intraoperative cell salvage (ICS) is a method to collect and process red blood cells (RBCs) from the blood lost ...
Bo Lei +6 more
doaj +1 more source
Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study [PDF]
, 2018 The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a ...
Antimo Cutone +6 more
core +2 more sources
Enhanced detection of fetal pose in 3D MRI by Deep Reinforcement Learning with physical structure priors on anatomy [PDF]
arXiv, 2020 Fetal MRI is heavily constrained by unpredictable and substantial fetal motion that causes image artifacts and limits the set of viable diagnostic image contrasts. Current mitigation of motion artifacts is predominantly performed by fast, single-shot MRI and retrospective motion correction.
arxiv
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.
Blood, 2016 Induction of red blood cell (RBC) fetal hemoglobin (HbF; α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS; α2βS2) to inhibit its polymerization.
Yankai Zhang +7 more
semanticscholar +1 more source
Oxygen targeting in preterm infants: a physiological interpretation. [PDF]
, 2015 Randomized controlled trials evaluating low-target oxygen saturation (SpO2:85% to 89%) vs high-target SpO2 (91% to 95%) have shown variable results regarding mortality and morbidity in extremely preterm infants.
Lakshminrusimha, S +3 more
core