Results 91 to 100 of about 519,319 (293)

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Persistent fetal pulmonary hypoperfusion after acute hypoxia

, 1987
To determine the effects of duration of hypoxia on fetal pulmonary blood flow and vasoreactivity, we studied the response of the fetal pulmonary vascular bed before, during, and after prolonged (2-h) and more brief (30-min) exposures to acute hypoxia in
S. H. Abman, G. Meschia, R. B. Wilkening, F. J. Accurso   +3 more
core   +1 more source

Amniotic fluid embolism as an immunocoagulatory catastrophic anaphylactoid syndrome

Акушерство, гинекология и репродукция
Amniotic fluid embolism (AFE) is a rare, life-threatening obstetric complication, known in modern terminology as anaphylactoid syndrome of pregnancy (ASP).
A. R. Oskolkova, A. R. Khisamieva, V. O. Bitsadze, J. Kh. Khizroeva, N. A. Makatsariya, M. V. Tretyakova, N. R. Gashimova, K. N. Grigoreva, O. Yu. Panfilova, J.-Ch. Gris, I. Elalamy, G. Gerotziafas, E. D. Makatsariya   +12 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Alterações anatomopatológicas da placenta e variações do índice de Apgar Anatomic and pathological placenta alterations and Apgar score variations

Revista Brasileira de Saúde Materno Infantil, 2006
OBJETIVOS: descrever possíveis alterações anatomopatológicas placentárias associadas à hipóxia fetal, avaliada pelo índice de Apgar. MÉTODOS: foram estudadas 167 placentas de partos realizados no Hospital Escola da Universidade Federal do Triângulo ...
Rosana Rosa Miranda Corrêa, Ana Karina Marques Salge, Gustavo Augusto Ribeiro, Mara Lúcia Fonseca Ferraz, Marlene Antônia dos Reis, Eumenia Costa da Cunha Castro, Vicente de Paula Antunes Teixeira   +6 more
doaj   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

EFFECTS OF ACOUSTIC STIMULATION ON BIOPHYSICAL PROFILE TESTING TIME [PDF]

Biophysical profile (BPP) test is the most commonly used antenatal test of fetal well-being. Purpose of this study is determining the influence of acoustic stimulation (AS) on BPP testing time.
رفاهی, سهیلا, جاوید مجد, مریم, مردی, افروز, پورعیسی, مسعود   +3 more
core  

Hypoxia and Fetal Programming of Cardiovascular Dysfunction [PDF]

, 2010
Human epidemiological studies have shown a clear association of adverse intrauterine environment and an increased risk of ischemic heart disease in later adult life.
Xue, Qin
core   +1 more source

Conserved gene expression patterns in the placenta underlie pregnancy complications associated with hypoxia in mice and humans

Cellular and Molecular Life Sciences
During pregnancy hypoxia leads to complications like fetal growth restriction (FGR). Maternal inhalation hypoxia during late murine pregnancy impairs placental phenotype and fetal development in a severity-dependent manner.
Emma J Siragher, Josephine S Higgins, Owen R Vaughan, Abigail L Fowden, Amanda N Sferruzzi-Perri   +4 more
doaj   +1 more source