Results 111 to 120 of about 110,385 (298)

Uptake of exogenous substrates during hypoxia in fetal lambs

, 1988
Fetal uptakes of oxygen, glucose, lactate, and alpha-amino-nitrogen containing substrates were measured in eight near-term fetal lambs by simultaneously drawing blood samples from the umbilical vein and descending aorta, then measuring umbilical blood ...
J. R. Milley
core   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

The Correlation Between Fetal Wellbeing and Umbilical Doppler Parameters in Pregnant Women with Gestational Hypertension

International Journal of Women's Health
Hualan Lin, Meifang Shen, Dongbei Li, Qiuxia Sun, Liubing Lan Obstetrical Department, Meizhou people’s Hospital, Meizhou City, Guangdong Province, 514000, People’s Republic of ChinaCorrespondence: Liubing Lan, Obstetrical Department, Meizhou people’s ...
Lin H, Shen M, Li D, Sun Q, Lan L
doaj  

Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model. [PDF]

Biomedicines, 2021
Illa M, Pla L, Berdún S, Mir M, Rivas L, Dulay S, Picard-Hagen N, Samitier J, Gratacós E, Eixarch E.   +9 more
europepmc   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Acute-on-chronic: using magnetic resonance imaging to disentangle the haemodynamic responses to acute and chronic fetal hypoxaemia

Frontiers in Medicine
IntroductionThe fetal haemodynamic response to acute episodes of hypoxaemia are well characterised. However, how these responses change when the hypoxaemia becomes more chronic in nature such as that associated with fetal growth restriction (FGR), is ...
Jack R. T. Darby, Brahmdeep S. Saini, Stacey L. Holman, Sarah J. Hammond, Sunthara Rajan Perumal, Christopher K. Macgowan, Mike Seed, Mike Seed, Janna L. Morrison, Janna L. Morrison, Janna L. Morrison   +10 more
doaj   +1 more source

The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain. [PDF]

Oxid Med Cell Longev, 2022
Muccini AM, Tran NT, Hale N, McKenzie M, Snow RJ, Walker DW, Ellery SJ.   +6 more
europepmc   +1 more source

Metabolic adaptation of fetal hindlimb to severe, nonlethal hypoxia

, 1992
To test the hypothesis that an important aspect of the fetal response to severe, nonlethal hypoxia is a relatively large reduction in oxidative metabolism and small increase in lactate production by organs whose O2 supply is selectively reduced, net ...
G. Meschia, D. W. Boyle, R. B. Wilkening
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection. [PDF]

BMC Vet Res, 2021
Malgarin CM, Moser F, Pasternak JA, Hamonic G, Detmer SE, MacPhee DJ, Harding JCS.   +6 more
europepmc   +1 more source