Results 141 to 150 of about 110,385 (298)

Intrapartum zigzag pattern of fetal heart rate is an early sign of fetal hypoxia: A large obstetric retrospective cohort study. [PDF]

Acta Obstet Gynecol Scand, 2021
Tarvonen M, Hovi P, Sainio S, Vuorela P, Andersson S, Teramo K.   +5 more
europepmc   +1 more source

Impact of experimental diabetes and chronic hypoxia on rat fetal body weight

, 2018
Objectives: The aim of the study is to determine the impact of the experimental diabetes and the chronic hypoxia on pregnancy development and rat fetal body weight. Material and methods: The experiment was performed on female Wistar rats.
Billewicz-Kraczkowska, Aleksandra; Department of Pediatric Propedeutics, Medical University of Lublin, Lublin, Poland, 6 Gębali Street, 20-093 Lublin, Poland, Pedrycz, Agnieszka; Department of Histology and Embryology, Medical University of Lublin, Lublin, Poland, 11 Radziwiłłowska Street, 20-080 Lublin, Poland, Robak, Jacek Marcin; Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland, Karwasik-Kajszczarek, Katarzyna; Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland, Chmiel-Perzyńska, Iwona; Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Lublin, Poland, 8B Jaczewskiego Street, 20-090 Lublin, Poland, Smoleń, Agata; Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Lublin, Poland, 1 Chodźki Street, 20-093 Lublin, Poland, Kraczkowski, Janusz Jacek; Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland   +6 more
core   +1 more source

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Placental delayed villous maturation is associated with evidence of chronic fetal hypoxia. [PDF]

J Perinat Med, 2020
Jaiman S, Romero R, Pacora P, Jung EJ, Kacerovsky M, Bhatti G, Yeo L, Hsu CD.   +7 more
europepmc   +1 more source

Hypoxia regulated pathways in urological malignancies

, 2009
Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses inthe UK each year. Patient survival has improved over the past few decades; however themechanisms of this are yet to be fully elucidated.
Charlesworth, Philip J.S., Charlesworth, Philip J S   +1 more
core  

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source