Results 261 to 270 of about 850,904 (382)

Amplifying Anti‐Tumor Immune Responses via Mitochondria‐Targeting Near‐Infrared Photodynamic Therapy

Advanced Science, EarlyView.
Interfacial Nd3+‐triplet energy transfer enables direct activation of molecular triplets under near‐infrared (NIR) irradiation for reactive oxygen species (ROS) generation. Photodynamic therapy (PDT) exaggerates hypoxia, which initiates subsequent hypoxia‐activated chemotherapy.
Cheng‐Ao Li, Junjie Nan, Qingxuan Ye, Bingzhu Zheng, Xiaomeng Dai, Jingya Li, Feng Wang, Huimin Ma, Yu Cheng, Jian Ruan, Weijia Fang, Peng Zhao, Renren Deng, Dong Cen   +13 more
wiley   +1 more source

750: Preeclampsia (PE) enhances NGAL expression at fetal-maternal interface: role of iron and hypoxia [PDF]

, 2012
Errol R. Norwitz, Serkalem Tadesse, Zhonghua Tang, Seth Guller   +3 more
openalex   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Evolving changes in fetal heart rate variability and brain injury after hypoxia‐ischaemia in preterm fetal sheep

Journal of Physiology, 2018
K. Yamaguchi, Christopher A. Lear, Michael J. Beacom, T. Ikeda, A. Gunn, L. Bennet   +5 more
semanticscholar   +1 more source

Interpretable Active Learning Identifies Iron‐Doped Carbon Dots With High Photothermal Conversion Efficiency for Antitumor Synergistic Therapy

Aggregate, EarlyView.
On the basis of active learning strategy, we propose an equivalent value—SHapley Additive exPlanations equivalent value—to optimize carbon dots’ photothermal conversion efficiency. Within four iterations, iron‐doped carbon dots are synthesized with the efficiency exceeding 78.7%.
Tianliang Li, Bin Cao, Yitong Wang, Lixing Lin, Lifei Chen, Tianhao Su, Haicheng Song, Yuze Ren, Longhan Zhang, Yingying Chen, Zhenzhen Li, Lingyan Feng, Tong‐yi Zhang   +12 more
wiley   +1 more source

713: Impaired fetoplacental angiogenesis in fetal growth restriction is mediated by hypoxia inducible factor 1-beta (HIF1β) [PDF]

, 2013
Emily Su, Hong Xin, Linda M. Ernst, Serdar E. Bulun   +3 more
openalex   +1 more source

The fetal brain sparing response to hypoxia: physiological mechanisms

Journal of Physiology, 2016
D. Giussani
semanticscholar   +1 more source

Interfacial Engineering of Pillararene‐Modified Ceria Nanoparticles for Regulable Enhanced Sonodynamic Therapy

Aggregate, EarlyView.
The innovation of this work lies in the use of supramolecular interfacial effect of pillararene (CP5) to regulate the performance of CeOx by promoting the charge separation and transportation, which can enhance the SDT efficacy by large ROS generation and TME regulation.
Congcong Wang, Yanan Guo, Guoying Tan, Wanrong Kang, Wenjia Guo, Nan Song, Yu Tang   +6 more
wiley   +1 more source

Spontaneous Pre-Existing Hypoxia Does Not Affect Brain Damage after Global Cerebral Ischaemia in Late-Gestation Fetal Sheep [PDF]

, 2014
Joanne O. Davidson, Caroline A. Yuill, Guido Wassink, Laura Bennet, Alistair J. Gunn   +4 more
openalex   +1 more source