Animal models of fetal growth restriction: Considerations for translational medicine. [PDF]
, 2015 Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential. It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause of infant mortality and morbidity.
David, AL, Swanson, AM
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Journal of Physiology, 2020 Pregnancy at high altitude is associated with a greater incidence of fetal growth restriction due, in part, to lesser uterine artery blood flow. AMP‐activated protein kinase (AMPK) activation vasodilates arteries and may increase uterine artery blood ...
Sydney L. Lane +6 more
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A maternal high-fat diet induces fetal origins of NASH-HCC in mice
Scientific Reports, 2022 Maternal overnutrition affects offspring susceptibility to nonalcoholic steatohepatitis (NASH). Male offspring from high-fat diet (HFD)-fed dams developed a severe form of NASH, leading to highly vascular tumor formation.
Takao Takiyama +14 more
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Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications
Antioxidants, 2021 Hypoxia is a common and severe stress to an organism’s homeostatic mechanisms, and hypoxia during gestation is associated with significantly increased incidence of maternal complications of preeclampsia, adversely impacting on the fetal development and ...
Xiang-Qun Hu, Lubo Zhang
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Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro [PDF]
, 1993 Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.
Eckardt, Kai-Uwe +3 more
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Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. [PDF]
, 2019 Prenatal stem cell-based regenerative therapies have progressed substantially and have been demonstrated as effective treatment options for fetal diseases that were previously deemed untreatable. Due to immunoregulatory properties, self-renewal capacity,
Farmer, Diana L +7 more
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Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia [PDF]
, 2007 Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most ...
Cullinan, William E +2 more
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Fetal blood vessel count increases in compensation of hypoxia in premature placentas [PDF]
Universa Medicina, 2015 Background Prematurity refers to live births before 37 weeks of gestation, wherein the baby is born before the body and its organ systems achieve perfect maturity, and this disorder is still a global problem.
K. Kartini +4 more
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Low Fetal Resistance to Hypoxia as a Cause of Stillbirth and Neonatal Encephalopathy
Clinical and Experimental Obstetrics & GynecologyObjective: Low fetal resistance to hypoxia is a factor in stillbirth and neonatal encephalopathy. This review examines fetal movement patterns in response to hypoxia as a predictor of the likelihood of stillbirth.
Petr Shabanov +4 more
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Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]
, 2020 The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar +3 more
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