Results 81 to 90 of about 850,904 (382)

Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation

Scientific Reports, 2019
We investigated whether diet-induced changes in the maternal intestinal microbiota were associated with changes in bacterial metabolites and their receptors, intestinal inflammation, and placental inflammation at mid-gestation (E14.5) in female mice fed ...
Jessica G Wallace, Christian J. Bellissimo, Erica Yeo, Yu Fei Xia, J. Petrik, M. Surette, D. Bowdish, D. Sloboda   +7 more
semanticscholar   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes [PDF]

, 2017
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR).
Agustin Gutierrez, Jaime, Freeman, Dilys Jane, Jayabalan, Nanthini, Lappas, Martha, Leiva, Andrea, Nair, Soumyalekshmi, Nuzhat, Zarin, Rice, Gregory E., Salomon, Carlos, Sanhueza, Carlos, Sobrevia, Luis, Zúñiga, Felipe A.   +11 more
core   +2 more sources

Simulation of Single Channel Magnetic Induction Spectroscopy for Fetal Hypoxia Detection

, 2015
Conventional fetal scalp blood sampling (FBS) need an invasive measurement to detect fetal hypoxia in fetus. This paper describe non-invasive technique employing single channel magnetic induction technique.
Zulkarnay Zakaria, Shazwani Sarkawi, J. A. Jalil, Ibrahim Balkhis, Mohamad Aliff Abd Rahim, N. Mustafa, R. A. Rahim, M. Rahiman   +7 more
semanticscholar   +1 more source

Prenatal hypoxia-induced epigenomic and transcriptomic reprogramming in rat fetal and adult offspring hearts

Scientific Data, 2019
The molecular mechanism of antenatal hypoxia impacting on fetal heart development and elevated risk of heart disease of adult offspring is poorly understood.
Xin Chen, Lubo Zhang, Charles Wang
semanticscholar   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Fetal blood vessel count increases in compensation of hypoxia in premature placentas

Universa Medicina, 2016
BACKGROUND Prematurity refers to live births before 37 weeks of gestation, wherein the baby is born before the body and its organ systems achieve perfect maturity, and this disorder is still a global problem.
K Kartini, Ahmad A Jusuf, Sri Widia A Jusman, M Ekawati, Ani R Prijanti   +4 more
doaj   +1 more source

A deep feature fusion network for fetal state assessment

Frontiers in Physiology, 2022
CTG (cardiotocography) has consistently been used to diagnose fetal hypoxia. It is susceptible to identifying the average fetal acid-base balance but lacks specificity in recognizing prenatal acidosis and neurological impairment.
Yahui Xiao, Yaosheng Lu, Mujun Liu, Rongdan Zeng, Jieyun Bai   +4 more
doaj   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source