Abstract Purpose This registry study aimed to evaluate the safety and effectiveness of collagen membrane‐covered matrix‐associated autologous chondrocyte implantation (cMACI) versus periosteum‐covered MACI (pMACI) for large knee cartilage defects (Outerbridge III–IV, ≥4 cm²) in the femorotibial and/or patellofemoral joints with a minimum 2‐year follow ...
Yuji Uchio +4 more
wiley +1 more source
The Laryngeal Auditory Startle Reflex (LASR): A New Component of the Auditory Startle Response
The auditory startle reflex contains a distinct laryngeal component, termed the laryngeal auditory startle reflex (LASR). In healthy adults, the LASR is modulated by supratentorial influences and habituates to repetitive stimuli. Physiologic and pathologic implications for the LASR as a component of the overall human SR remain to be determined but may ...
Catherine F. Sinclair +4 more
wiley +1 more source
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo +10 more
wiley +1 more source
mTOR Signaling Pathway in Antiphospholipid Syndrome: Pathogenesis and Potential Therapeutic Targets. [PDF]
Huo R +5 more
europepmc +1 more source
ABSTRACT Background Glatiramer acetate is an injectable disease‐modifying therapy indicated for multiple sclerosis (MS). Aim To evaluate the real‐world safety and effectiveness of glatiramer acetate for MS in Japan. Methods A prospective, multicenter, observational, all‐case post‐marketing survey was conducted in Japan between November 2015 and March ...
Masaaki Niino +3 more
wiley +1 more source
The Self-amplifying Inflammatory Cascade in Obstetric Antiphospholipid Syndrome: From Pathophysiology to Placenta-centric Immunotherapeutic Targets. [PDF]
Yan R, Wei Y, Chen L, Zhu S, Dong X.
europepmc +1 more source
Histiocytosis development and clinical variation through the lens of genomics
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance. [PDF]
Ma ZJ +8 more
europepmc +1 more source
Neuroimaging Findings and Risk Factors for Brain Injury in Foetuses Treated for Anaemia
ABSTRACT Objective Characterize neuroimaging findings in foetuses with anaemia and identify associated risk factors. Methods Retrospective cohort study of pregnancies with foetal anaemia (defined as haemoglobin > 2 standard deviations below the gestational age mean) confirmed by foetal blood sampling (FBS) and treated with intrauterine transfusion (IUT)
Laurence Sophie Carmant +6 more
wiley +1 more source
Gestational Age-Dependent Associations Between Mycoplasma/Ureaplasma Colonization and Inflammatory Placental Lesions in Preterm Birth. [PDF]
Çetinkaya Demir B +5 more
europepmc +1 more source

