Results 191 to 200 of about 133,571 (269)

Prenatal Diagnosis and Management of Kaposiform Hemangioendothelioma With Kasabach–Merritt Phenomenon: Imaging Features and First Experience With Maternal Sirolimus Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To describe the prenatal diagnosis, evolution, and perinatal management of kaposiform hemangioendothelioma (KHE) complicated by the Kasabach–Merritt phenomenon (KMP), and to report the first documented use of maternal sirolimus therapy (MST) in this setting. Methods We retrospectively reviewed four fetuses with a prenatal soft‐tissue
Antoine Fraissenon, Chris Minella, Marion Bordas‐Fournel, Anne Gaëlle Grebille, Olivia Boccara, Marie Cassart, Sarah Simon‐Locatelli, Gwenaelle André, Guillaume Canaud, Alexandre Guilhem, Sara Cabet, Laurent Guibaud   +11 more
wiley   +1 more source

TORCH infections at the maternal-fetal placental transmission: an overview of multi-omics, pathogenesis and innate immune defense. [PDF]

Front Cell Infect Microbiol
Nirala S, Huang C, Mu Q.
europepmc   +1 more source

Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta‐Heart Axis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Concurrent development of the placenta and heart during early gestation suggests a shared biological basis for the co‐occurrence of abnormal placentation and congenital heart disease (CHD). This study investigated the association between placental vascular pathology and CHD type.
Natalie Lanners, Sarah U. Morton, Katherine Le, Steffy Blanco, Sara Mansoorshahi, Chrystalle Katte Carreon, Christina Ronai, Louise Wilkins‐Haug, Vidhya Annavajjhala, Jacqueline G. Parchem, Tina O. Findley   +10 more
wiley   +1 more source

Understanding Preeclampsia: Integrating Placental Dysfunction, Immune Dysregulation and microRNA-Mediated Epigenetic Regulation. [PDF]

Int J Mol Sci
Procopciuc LM, Caracostea GV, Hangan AC, Lucaciu RL.   +3 more
europepmc   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

The transformative potential of artificial intelligence in pediatric medicine: Current applications, methodological challenges, and future directions

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) offers transformative potential for paediatric diagnosis and treatment, yet implementation faces unique challenges, including data scarcity, algorithmic bias, and children's developmental physiology. This review examines current applications and charts a path toward transparent, equitable, and trustworthy AI in child health.
Ruisong Wang, Xiaoman Ding, Wanyue Zhang, Tieliu Shi   +3 more
wiley   +1 more source

The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review. [PDF]

Microorganisms
Stavros S, Gerede A, Zagorianakou N, Moustakli E, Potiris A, Anagnostaki I, Kozonis A, Tzeli M, Vogiatzoglou AL, Machairoudias P, Zacharis K, Zikopoulos A, Loutradis D, Domali E.   +13 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Nesfatin-1 across human reproduction and early life: implications for infertility, pregnancy complications, and lactation. [PDF]

Front Endocrinol (Lausanne)
Katona R, Filarszky D, Funke S, Vass RA.
europepmc   +1 more source