Proximo‐distal gradient of Na+‐dependent D‐glucose transport activity in the brush border membrane vesicles from the human fetal small intestine [PDF]
, 1987 Christiane Malo, A. Berteloot
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Optical coherence tomography of human fetal membrane sub-layers during loading. [PDF]
Biomed Opt Express, 2023 Samimi K +8 more
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A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury
EMBO Molecular Medicine, 2015 Group B streptococci (GBS) are Gram‐positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta.
Christopher Whidbey +13 more
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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]
, 2005 JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J. +3 more
core
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
The readmission of a parturient with natural delivery after discharge due to residual fetal membrane: A case report. [PDF]
Medicine (Baltimore), 2023 Wang Y, Li J, He Q, Ren J, Wang G.
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Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Fetal membrane at the feto-maternal interface: An underappreciated and understudied intrauterine tissue. [PDF]
Placenta Reprod Med, 2022 Richardson L, Menon R.
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