Results 131 to 140 of about 2,436,052 (292)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Polyvinylidene fluoride membrane modification via oxidant-induced dopamine polymerization for sustainable direct-contact membrane distillation

, 2018
Porous hydrophobic polyvinylidene fluoride (PVDF) membranes have been extensively used in direct-contact membrane distillation (DCMD) processes. However, these PVDF membranes are vulnerable to membrane fouling and pore wetting in low surface tension ...
Chandresh Malde, Rong Wang, Wang, Rong, Zhao, Shanshan, Chew, Nick Guan Pin, Shanshan Zhao, Malde, Chandresh, Nick Guan Pin Chew   +7 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Cell membrane protein coding genes which express more than 10 FPKM in either or both of adult and fetal corneal endothelial cells.

, 2015
Both: genes substantially expressed both in adult and fetal corneal endothelial cells.Adult: genes substantially expressed only in adult corneal endothelial cells.Fetal: genes substantially expressed only in fetal corneal endothelial cells.Cell membrane ...
Masahito Yoshihara (711952), Susumu Hara (711953), Motokazu Tsujikawa (1588), Satoshi Kawasaki (711954), Kohji Nishida (133839), Hiroko Ohmiya (215257), Yoshihide Hayashizaki (3101), Hideya Kawaji (13861), Masayoshi Itoh (15728)   +8 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

mRNA and Protein Expression in Human Fetal Membrane Cells: Potential Biomarkers for Preterm Prelabor Rupture of the Fetal Membranes? [PDF]

Int J Mol Sci, 2023
Mikkelsen E, Huppertz B, Singh R, Ravn K, Hatt L, Kruhøffer M, Urrabaz-Garza R, Uldbjerg N, Menon R, Steiniche T.   +9 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Optical coherence tomography of human fetal membrane sub-layers during loading. [PDF]

Biomed Opt Express, 2023
Samimi K, Contreras Guzman E, Wu M, Carlson L, Feltovich H, Hall TJ, Myers KM, Oyen ML, Skala MC.   +8 more
europepmc   +1 more source

Mathematical tools for identifying the fetal response to physical exercise during pregnancy [PDF]

, 2008
In the applied mathematics literature there exist a significant number of tools that can reveal the interaction between mother and fetus during rest and also during and after exercise.
Stirling, James, Barakat Carballo, Rubén O., Stirling, James R., Zakynthinaki, María S., Barakat Carballo, Ruben   +4 more
core  

Increased expression of ac-FoxO1 protein in prelabor fetal membranes overlying the cervix: Possible role in human fetal membrane rupture

, 2009
Forkhead box O proteins have critical roles in a number of cellular processes, including apoptosis. Acetylation and phosphorylation of forkhead box O proteins are posttranslational modifications that attenuate their transcriptional activity.
Martha Lappas, Clyde Riley, Rice, Greg E., Greg E. Rice, Lappas, Martha, Permezel, Michael, Michael Permezel, Riley, Clyde   +7 more
core   +1 more source