New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties [PDF]
Scientific Reports, 2022 Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indentation
Sudeshna Bhunia +5 more
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Functional Genomics of Healthy and Pathological Fetal Membranes [PDF]
Frontiers in Physiology, 2020 Premature preterm rupture of membranes (PPROM), rupture of fetal membranes before 37 weeks of gestation, is the leading identifiable cause of spontaneous preterm births.
Sarah J. Cunningham +9 more
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Fetal DNA Causes Sex-Specific Inflammation From Human Fetal Membranes [PDF]
Frontiers in Physiology, 2022 Inflammation is central to the mechanisms of parturition, but the lack of understanding of how it is controlled in normal parturition hampers our ability to understand how it may diverge resulting in preterm birth.
Chelsea A. Saito Reis +5 more
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Possible important roles of galectins in the healing of human fetal membranes [PDF]
Frontiers in Endocrinology, 2022 The fetal membranes healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers. Multiple cells and extracellular matrices, and cell differentiation, migration and proliferation may participate in ...
Jia-Le Chen +6 more
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Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The fetal membranes provide a supportive environment for the growing embryo and later fetus. Due to their versatile properties, the use of fetal membranes in tissue engineering and regenerative medicine is increasing in recent years.
Taja Železnik Ramuta +3 more
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Physiological TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case [PDF]
eLife, 2022 The integrity of human fetal membranes is crucial for harmonious fetal development throughout pregnancy. Their premature rupture is often the consequence of a physiological phenomenon that has been exacerbated. Beyond all the implied biological processes,
Corinne Belville +7 more
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Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta [PDF]
Frontiers in Immunology, 2023 The close interaction between fetal and maternal cells during pregnancy requires multiple immune-endocrine mechanisms to provide the fetus with a tolerogenic environment and protection against any infectious challenge.
Pilar Flores-Espinosa +8 more
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Cortisol Regeneration in the Fetal Membranes, A Coincidental or Requisite Event in Human Parturition? [PDF]
Frontiers in Physiology, 2020 The fetal membranes are equipped with high capacity of cortisol regeneration through the reductase activity of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). The expression of 11β-HSD1 in the fetal membranes is under the feedforward induction by cortisol,
Wang-Sheng Wang +4 more
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Occurrence of a RAGE-Mediated Inflammatory Response in Human Fetal Membranes [PDF]
Frontiers in Physiology, 2020 Context:Sterile inflammation has been shown to play a key role in the rupture of the fetal membranes (FMs). Moreover, an early and exacerbated runaway inflammation can evolve into a preterm premature rupture of membranes and lead to potential preterm ...
Héléna Choltus +10 more
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Birth mode is associated with layer-specific mechanical changes in fetal membranes [PDF]
Scientific ReportsRupture of fetal membranes and subsequent full-term birth are prerequisites for neonatal health, and a preterm rupture can lead to life-threatening complications.
Philip Friedrich +11 more
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