Results 61 to 70 of about 375,721 (291)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

DIAGNOSTIC CONFIRMATION OF THE EVALUATION OF THE TRACING OF ELECTRONIC FETAL MONITORING BASED ON PROBABILITY AND THE S/k RATIO OF ENTROPY

Momento, 2018
The correct interpretation of the layout of fetal monitoring is a challenge for current clinical; recently a diagnostic methodology based on the theories of probability and entropy, which managed to assess in an objective and reproducible way the layout ...
Yolanda Soracipa, Javier Rodríguez, Marcos Castillo   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of social support on fetal movement self-monitoring behavior in Chinese women: a moderated mediation model of health beliefs

Journal of Psychosomatic Obstetrics and Gynecology
Objective Strengthening the management of women’s self-monitoring during pregnancy is important to reduce fetal death in utero and improve maternal and infant outcomes.
Changmin Niu, Yue Xie, Wangxuan Zhou, Yue Ren, Ying Zheng, Lin Li   +5 more
doaj   +1 more source

Intelligent Structured Intermittent Auscultation (ISIA): Evaluation of a decision-making framework for fetal heart monitoring of low-risk women [PDF]

, 2014
Background: Research-informed fetal monitoring guidelines recommend intermittent auscultation (IA) for fetal heart monitoring for low-risk women. However, the use of cardiotocography (CTG) continues to dominate many institutional maternity settings ...
Foureur, MJ, Maude, RM, Skinner, JP
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Atrioventricular conduction abnormalities are associated with poor outcome following intermittent umbilical cord occlusions in fetal sheep

Acta Obstetricia et Gynecologica Scandinavica
Introduction Fetal arrhythmias have been described with intrapartum hypoxemia; however, they cannot be accurately diagnosed with currently used fetal heart rate (FHR) monitoring systems due to low resolution and signal averaging.
Juulia Lantto, Jonas Johnson, Heikki Huhta, Mervi Haapsamo, Panu Kiviranta, Kati Räsänen, Hanna‐Marja Voipio, Sven‐Erik Sonesson, Juha Voipio, Juha Räsänen, Ganesh Acharya   +10 more
doaj   +1 more source

Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review

Sensors, 2018
This article reviews existing clinical practices and sensor research undertaken to monitor fetal well-being during labour. Current clinical practices that include fetal heart rate monitoring and fetal scalp blood sampling are shown to be either ...
Gerard Cummins, Jessica Kremer, Anne Bernassau, Andrew Brown, Helen L. Bridle, Holger Schulze, Till T. Bachmann, Michael Crichton, Fiona C. Denison, Marc P. Y. Desmulliez   +9 more
doaj   +1 more source

Fetal heart rate monitoring practices at a public hospital in Northern Uganda – what health workers document, do and say

Global Health Action, 2020
Background: In Uganda, perinatal mortality is 38 per 1000 pregnancies. One-third of these deaths are due to birth asphyxia. Adequate fetal heart rate (FHR) monitoring during labor may detect birth asphyxia but little is known about monitoring practices ...
Elizabeth Ayebare, Wibke Jonas, Grace Ndeezi, Jolly Nankunda, Claudia Hanson, James K. Tumwine, Anna Hjelmstedt   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source