Results 101 to 110 of about 7,077,080 (366)

Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]

, 2020
To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju, Duan, Yaoyun, Fan, Feifei, Fang, Xi, Huang, Lei, Jia, Nan, Li, Yali, Liu, Jie, Ouyang, Kunfu, Tang, Huayuan, Trexler, Christa, Wang, Gang, Wang, Hong, Yang, Feili   +13 more
core  

Herculin, a Fourth Member of the MyoD Family of Myogenic Regulatory Genes [PDF]

, 1990
We have identified and cloned herculin, a fourth mouse muscle regulatory gene. Comparison of its DNA and deduced amino acid sequences with those of the three known myogenic genes (MyoD, myogenin, and Myf-5) reveals scattered short spans with similarity ...
Miner, Jeffrey H., Wold, Barbara J.
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Large-scale discovery of enhancers from human heart tissue. [PDF]

, 2011
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers.
Afzal, Veena, Akiyama, Jennifer A, Black, Brian L, Blow, Matthew J, Bristow, James, Holt, Amy, Jensen, Brian C, Kaplan, Tommy, May, Dalit, McCulley, David J, Pennacchio, Len A, Plajzer-Frick, Ingrid, Rubin, Edward M, Shoukry, Malak, Simpson, Paul C, Visel, Axel, Wright, Crystal   +16 more
core  

Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. [PDF]

, 2010
Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L.
A Beham, A Le Monnier, A Moffett, A Shen, AI Bakardjiev, AI Bakardjiev, AI Bakardjiev, AJ Teberg, AM Carter, Anna I. Bakardjiev, AV Lallemand, B Swaminathan, BF King, C Coutifaris, C Floridon, C Kocks, C Sundstrom, CA Kirkbride, CD Ockleford, DA Drevets, DA Drevets, DA Portnoy, DA Portnoy, David S. Schneider, DK Bishop, E Maidji, E Mylonakis, EG Pamer, G Scheuner, H Bierne, H Koi, HM Cobe, IJ Glomski, J Mengaud, J Skoble, J Trowsdale, JA Theriot, Jennifer R. Robbins, JR Robbins, K Benirschke, K Red-Horse, K Red-Horse, Kasia M. Skrzypczynska, KS Kim, L Forner, L Vicovac, LG Tilney, LM Brown, M Berryman, M Lecuit, M Lecuit, M Lecuit, M O'Riordan, M Pentecost, Mirhan Kapidzic, NM Hunkapiller, O Disson, O Genbacev, O Genbacev, O Genbacev, P Cossart, PB Medawar, PD Barnes, PM Drake, RK Miller, RL Goldenberg, S Fisher, S Jones, S Kaur, S Notermans, SJ Cantle, SJ Fisher, SJ Fisher, SR Sooranna, T Kajii, T Rajabian, T Wollert, TH Schiebler, Varvara B. Zeldovich, Y Huang, Y Shen, Y Zhou, Z Vacek   +82 more
core   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation. [PDF]

, 1997
We have detected DNA binding activity for a synthetic oligonucleotide containing an Sp1 consensus sequence in nuclear extracts from human chondrocytes. Changes in the levels of Sp1 oligonucleotide binding activity were examined in nuclear extracts from ...
Dharmavaram, Rita M., Jimenez, Sergio A., Liu, Gang, Mowers, Sheryl D.   +3 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The role of pleiotrophin and β-catenin in fetal lung development

Respiratory Research, 2010
Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins.
Weng Tingting, Liu Lin
doaj   +1 more source