Results 11 to 20 of about 742,478 (265)

Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model

Disease Models & Mechanisms, 2018
Osteoarthritis (OA), a degenerative joint disease characterized by progressive cartilage degeneration, is one of the leading causes of disability worldwide owing to the limited regenerative capacity of adult articular cartilage.
Iris Ribitsch, Rupert L. Mayer, Monika Egerbacher, Simone Gabner, Maciej M. Kańduła, Julie Rosser, Eva Haltmayer, Ulrike Auer, Sinan Gültekin, Johann Huber, Andrea Bileck, David P. Kreil, Christopher Gerner, Florien Jenner   +13 more
doaj   +1 more source

Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed

Journal of Animal Science and Biotechnology, 2018
Background The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows (a fat breed with excellent maternal ability) have a higher survival
F. Gondret, B. Guével, M. C. Père, H. Quesnel, Y. Billon, E. Com, L. Canario, I. Louveau, L. Liaubet   +8 more
doaj   +1 more source

Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction

The Journal of Clinical Investigation, 2023
BACKGROUND Severe, early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, thus preventing accurate patient counseling.
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Maršál, Francesc Figueras, Gareth Ambler, Harry Whitwell, Nuno Rocha Nené, Neil J. Sebire, Stefan R. Hansson, Anke Diemert, Jana Brodszki, Eduard Gratacós, Yuval Ginsberg, Tal Weissbach, Donald M. Peebles, Ian Zachary, Neil Marlow, Angela Huertas-Ceballos, Anna L. David   +19 more
doaj   +1 more source

Profiling extra cellular matrix associated proteome of human fetal nucleus pulposus in search for regenerative targets

Scientific Reports, 2021
Degeneration of the intervertebral disc is associated with a decrease in extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic signaling.
Shanmuganathan Rajasekaran, Chitra Thangavel, Niek Djuric, Muthurajan Raveendran, Dilip Chand Raja Soundararajan, Sharon Miracle Nayagam, Monica Steffi Matchado, K. S. Sri Vijay Anand, Krishna Venkateshwaran   +8 more
doaj   +1 more source

Epigenomic and Proteomic Changes in Fetal Spleens Persistently Infected with Bovine Viral Diarrhea Virus: Repercussions for the Developing Immune System, Bone, Brain, and Heart

Viruses, 2022
Bovine viral diarrhea virus (BVDV) infection during early gestation results in persistently infected (PI) immunotolerant calves that are the primary reservoirs of the virus. Pathologies observed in PI cattle include congenital defects of the brain, heart,
Hanah M. Georges, Hana Van Campen, Helle Bielefeldt-Ohmann, Thomas R. Hansen   +3 more
doaj   +1 more source

Placental proteome abnormalities in women with gestational diabetes and large-for-gestational-age newborns

BMJ Open Diabetes Research & Care, 2020
Introduction Gestational diabetes mellitus (GDM) is the most frequent metabolic complication during pregnancy and is associated with development of short-term and long-term complications for newborns, with large-for-gestational-age (LGA) being ...
Irene Cetin, Emma Assi, Francesca D'Addio, Chiara Mandò, Anna Maestroni, Cristian Loretelli, Moufida Ben Nasr, Vera Usuelli, Ahmed Abdelsalam, Andy Joe Seelam, Ida Pastore, Cinzia Magagnotti, Reza Abdi, Basset El Essawy, Franco Folli, Domenico Corradi, Gianvincenzo Zuccotti, Paolo Fiorina   +17 more
doaj   +1 more source

An appropriate level of autophagy reduces emulsified isoflurane-induced apoptosis in fetal neural stem cells

Neural Regeneration Research, 2020
Autophagy plays essential roles in cell survival. However, the functions and regulation of the autophagy-related proteins Atg5, LC3B, and Beclin 1 during anesthetic-induced developmental neurotoxicity remain unclear.
Ze-Yong Yang, Lei Zhou, Qiong Meng, Hong Shi, Yuan-Hai Li   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

4D-DIA proteomic analysis of human placenta in fetal intrauterine growth restriction

Frontiers in Medicine
IntrodutionApproximately 60% of fetal intrauterine growth restriction (FGR) cases result from placental dysfunction. 4D-DIA proteomic chips can efficiently identify differentially expressed proteins (DEPs), to explore FGR pathophysiology mechanism caused
Yuanyuan Dang, Yuanyuan Dang, Yuanyuan Dang, Xiaoxiao Kong, Xiaoxiao Kong, Xiaoxiao Kong, Tian Yang, Tian Yang, Tian Yang, Qiuhong Yu, Qiuhong Yu, Qiuhong Yu, Ping Chen, Ping Chen, Ping Chen, Mingli Lyu, Mingli Lyu, Mingli Lyu   +17 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source