Results 41 to 50 of about 742,478 (265)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Involvement of GDNF in Neuronal Protection against 6-OHDA-Induced Parkinsonism Following Intracerebral Transplantation of Fetal Kidney Tissues in Adult Rats

Neurobiology of Disease, 2001
Exogenous application of transforming growth factors-β (TGFβ) family proteins, including glial cell line-derived neurotrophic factor (GDNF), neurturin, activin, and bone morphogenetic proteins, has been shown to protect neurons in many models of ...
C.V. Borlongan, F.C. Zhou, T. Hayashi, T.-P. Su, B.J. Hoffer, Y. Wang   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Exploratory Urinary Proteomic Profiling in Pregnancies with Fetal Aneuploidies: Molecular Insights into Maternal–Fetal Metabolic Communication

Current Issues in Molecular Biology
Maternal–fetal communication involves complex molecular exchanges that can be perturbed by chromosomal abnormalities. Despite the growing use of omics approaches in prenatal research, maternal urine remains underexplored as a non-invasive source of ...
Răzvan Lucian Jurca, Maria-Andreea Soporan, Ioana-Ecaterina Pralea, Ioana Gheorghiu, Iulia Rus, Florin Stamatian, Cristina-Adela Iuga   +6 more
doaj   +1 more source

Proteomic profiling of human amnion for preterm birth biomarker discovery

Scientific Reports, 2021
Spontaneous preterm birth (PTB) complicates about 12% of pregnancies worldwide, remaining the main cause of neonatal morbidity and mortality. Spontaneous preterm birth PTBs is often caused by microbial-induced preterm labor, mediated by an inflammatory ...
Maurizio Bruschi, Martina Bartolucci, Andrea Petretto, Francesca Buffelli, Xhuliana Kajana, Alessandro Parodi, Riccardo Carbone, Ezio Fulcheri, Luca Antonio Ramenghi, Isabella Panfoli, Giovanni Candiano   +10 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Human Cytomegalovirus Dysregulates Cellular Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases and Sonic Hedgehog Pathway Proteins in Neural Astrocyte and Placental Models

Viruses
Human cytomegalovirus (CMV) infection is the leading non-genetic cause of congenital malformation in developed countries, causing significant fetal injury, and in some cases fetal death.
Ece Egilmezer, Stuart T. Hamilton, Glen Lauw, Jasmine Follett, Eric Sonntag, Martin Schütz, Manfred Marschall, William D. Rawlinson   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Deregulated protein homeostasis constrains fetal hematopoietic stem cell pool expansion in Fanconi anemia

Nature Communications
Demand-adjusted and cell type specific rates of protein synthesis represent an important safeguard for fate and function of long-term hematopoietic stem cells.
Narasaiah Kovuru, Makiko Mochizuki-Kashio, Theresa Menna, Greer Jeffrey, Yuning Hong, Young me Yoon, Zhe Zhang, Peter Kurre   +7 more
doaj   +1 more source

The characterization of preterm newborn saliva by top-down proteomic as a stimulus for the study of human development. A review of the results obtained over the past 25 years

Journal of Pediatric and Neonatal Individualized Medicine
Around the first years of 2000, our teams, at the Cagliari and Catholic-Policlinico Gemelli (Rome) Universities, started an investigation of the in­tact proteins of human saliva by a top-down pipeline.
Tiziana Cabras, Barbara Manconi, Alessandra Olianas, Maria Teresa Sanna, Cristina Contini, Giulia Guadalupi, Antonella Fiorita, Lea Calò, Gaetano Paludetti, Emanuele Scarano, Chiara Tirone, Giovanni Vento, Simona Fattore, Nicoletta Menzella, Davide De Tomaso, Federica Iavarone, Irene Messana, Claudia Desiderio, Diana Valeria Rossetti, Matteo Fraschini, Vassilios Fanos, Jacopo Galli, Gavino Faa, Massimo Castagnola   +23 more
doaj   +1 more source