Results 41 to 50 of about 2,560,680 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Imagawa, K., Richard O C Oreffo, de Andrés María C., Gonzalez, A., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Oreffo, R.O., Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Gomez-Reino, J.J., Emmajayne Kingham, Kei Imagawa, María C de Andrés, Wilson, D.I., Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Roach, H.I., Kingham, E., Gonzalez Antonio, de Andrés, M.C.   +34 more
core   +1 more source

Unique metabolism and protein expression signature in human decidual NK cells

Frontiers in Immunology, 2023
Human decidual natural killer (dNK) cells are a unique type of tissue-resident NK cells at the maternal-fetal interface. dNK cells are likely to have pivotal roles during pregnancy, including in maternal-fetal immune tolerance, trophoblast invasion, and ...
Ping Wang, Ping Wang, Tingting Liang, Tingting Liang, Heqin Zhan, Mingming Zhu, Mingming Zhu, Mingming Wu, Mingming Wu, Lili Qian, Ying Zhou, Fang Ni, Fang Ni   +12 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus concepti and not correlated with fetal weight [PDF]

, 2013
The insulin-like growth factor 2 receptor (IGF2R) is essential for prenatal growth regulation and shows gene dosage effects on fetal weight that can be affected by in-vitro embryo culture.
Eckhard Wolf, Horst-Dieter Reichenbach, Ivica Medugorac, Reichenbach Myriam, Stefan Hiendleder (103381), Susanne E. Ulbrich (116395), Hiendleder Stefan, Ulbrich, S., Stefan Hiendleder, Fürst, Rainer W, Bebbere, D., Daniela Bebbere (400357), Horst-Dieter Reichenbach (212841), Wolf Eckhard, Rainer W. Fürst (385591), Ulbrich, Susanne E., Reichenbach, M., Reichenbach, H., Reichenbach Horst-Dieter, Bauersachs, Stefan, Wolf, E., Fürst, Rainer W., Ulbrich, Susanne E, Rainer W Fürst, Eckhard Wolf (39870), Reichenbach, Myriam, Bebbere Daniela, Furst, R., Stefan Bauersachs (130224), Hiendleder, S., Bauersachs Stefan, Susanne E Ulbrich, Sergio Ledda (400358), Reichenbach, Horst-Dieter, Myriam Reichenbach, Myriam Reichenbach (212830), Medugorac, I., Medugorac Ivica, Stefan Bauersachs, Hiendleder, Stefan, Bebbere, Daniela, Bauersachs, S., Ledda Sergio, Sergio Ledda, Ledda, S., Ivica Medugorac (157507), Wolf, Eckhard, Fürst Rainer W., Medugorac, Ivica, Ledda, Sergio, Daniela Bebbere, Ulbrich Susanne E.   +51 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Proteins

, 2004
Solvation energy calculation is one of the main difficulties for the estimation of protein-ligand binding free energy and the correct scoring in docking studies.
Zhou, JJ, Wang, Q, Pei, JF, Lai, LH
core   +1 more source

Molecular bases of the excretion of fetal bile acids and pigments through the fetal liver-placenta-maternal liver pathway

Annals of Hepatology, 2005
Since the excretion of potentially toxic cholephilic organic anions (COAs) produced by the fetus, such as bile acids and biliary pigments, cannot be performed by the fetal liver alone, the placenta and the maternal liver must play a key role ...
José J.G. Marín, Rocio I.R. Macías, Óscar Briz, M.J. Pérez, María Ángeles Serrano   +4 more
doaj   +1 more source

S‐Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S‐Nitrosylation and Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S‐nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and ...
Shathiyah Kulandavelu, Raul A. Dulce, Christopher I. Murray, Michael A. Bellio, Julia Fritsch, Rosemeire Kanashiro‐Takeuchi, Himanshu Arora, Ellena Paulino, Daniel Soetkamp, Wayne Balkan, Jenny E. Van Eyk, Joshua M. Hare   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source