Results 41 to 50 of about 1,031,554 (306)

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. [PDF]

PLoS ONE, 2011
The uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty
Takuya Mishima, Jeffrey H Miner, Mayumi Morizane, Andreas Stahl, Yoel Sadovsky   +4 more
doaj   +1 more source

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. [PDF]

, 2017
PurposeThe RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose their specialized phenotype after multiple passages ...
Duncan, Todd, Jaworski, Cynthia, Kutty, R Krishnan, Lakkaraju, Aparna, Poliakov, Eugenia, Postnikova, Olga A, Redmond, T Michael, Samuel, William, Tan, Li Xuan   +8 more
core   +2 more sources

The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]

, 1974
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core   +1 more source

Regulation of stanniocalcin-1 secretion by BeWo cells and first trimester human placental tissue from normal pregnancies and those at increased risk of developing preeclampsia. [PDF]

, 2020
Stanniocalcin-1 (STC-1) is a multi-functional glycosylated peptide present in the plasma of healthy women postpartum and increased further in pregnancies complicated by preeclampsia. Although the STC-1 gene is expressed by the placenta what regulates its
Asma Khalil, Baskaran Thilaganathan, Guy S. Whitley, Joan Embola, Judith E. Cartwright, Julia Bercher, Kim LC, Ma X, Naila Abid, Salnikow K, Sandra V. Ashton, Trindade DM, Wallace AE, Zoe Tryfonos   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Microanatomy of the enteric neurons and glia; expression patterns of the PGP9.5, S100b proteins, RET and SOX10 genes in the human fetal gut wall

Translational Research in Anatomy
Background: Enteric nervous system comprises enteric neurons and glia, derived from neural crest cells, and regulates the gastrointestinal function. Previous animal studies have highlighted the essential roles of RET and SOX10 genes, along with PGP9.5 ...
Chacchu Bhattarai, Phanindra Prasad Poudel, Arnab Ghosh, Saman Man Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, Vani Lakshmi R, Sujan Gautam, Sneha Guruprasad Kalthur   +11 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

METTL13 methylation of eEF1A increases translational output to promote tumorigenesis [PDF]

, 2019
Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to ...
Bassik, Michael Cory, Caporicci, Marcello, Carlson, Scott Moore, Elias, Joshua Eric, Francis, Joel William, Fuentes, Mary Esmeralda, Gozani, Or, Hausmann, Simone, Hulea, Laura, Kim, Michael Paul, Li, Ami, Liu, Shuo, Lofgren, Shane Michael, Lu, Jiuwei, Maitra, Anirban, Mazur, Pawel Karol, Nicholas, Dang Nguyen, Pillai, Renjitha, Porco, John Anthony, Song, Jikui, Tandoc, Kristofferson, Topisirovic, Ivan, Van Rechem, Capucine, Wang, Huamin, Wistuba, Ignacio Ivan   +24 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source