Results 51 to 60 of about 2,560,680 (304)

Microanatomy of the enteric neurons and glia; expression patterns of the PGP9.5, S100b proteins, RET and SOX10 genes in the human fetal gut wall

Translational Research in Anatomy
Background: Enteric nervous system comprises enteric neurons and glia, derived from neural crest cells, and regulates the gastrointestinal function. Previous animal studies have highlighted the essential roles of RET and SOX10 genes, along with PGP9.5 ...
Chacchu Bhattarai, Phanindra Prasad Poudel, Arnab Ghosh, Saman Man Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, Vani Lakshmi R, Sujan Gautam, Sneha Guruprasad Kalthur   +11 more
doaj   +1 more source

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. [PDF]

PLoS ONE, 2011
The uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty
Takuya Mishima, Jeffrey H Miner, Mayumi Morizane, Andreas Stahl, Yoel Sadovsky   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey

Nature Communications, 2023
Fetal stages are critical periods for brain development. However, the protein molecular signature and dynamics of the human brain remain unclear due to sampling difficulty and ethical limitations.
Jingkuan Wei, Shaoxing Dai, Yaping Yan, Shulin Li, Pengpeng Yang, Ran Zhu, Tianzhuang Huang, Xi Li, Yanchao Duan, Zhengbo Wang, Weizhi Ji, Wei Si   +11 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A cross-sectional examination of immune adaptations during pregnancy in the ECHO Cohort

Frontiers in Immunology
BackgroundPregnancy requires finely tuned immune changes that support implantation, placental development, maternal–fetal tolerance, and preparation for labor, yet the normative trajectories of circulating inflammatory proteins across gestation remain ...
Sarah M. Banker, Rosa Shapiro-Thompson, Sarah Sinsel, Akhgar Ghassabian, Christian Douglas, Morgan E. Nelson, Lisa A. Peterson, Bharat Thyagarajan, Santiago Morales, Christine W. Hockett, Christine W. Hockett, Amy J. Elliott, Amy J. Elliott, Stephanie N. Giamberardino, Lauren C. Shuffrey   +14 more
doaj   +1 more source

Screening circulating proteins to identify biomarkers of fetal macrosomia

BMC Research Notes, 2019
Objective Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal traumatic injuries, and perinatal death.
Tess Cruickshank, Tu’uhevaha J. Kaitu’u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M. Dane, Anna L. Middleton, Valerie P. Kyritsis, Roxanne Hastie, Stephen Tong, Susan P. Walker, Teresa M. MacDonald   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Neuroprotective peptide ADNF-9 in fetal brain of C57BL/6 mice exposed prenatally to alcohol

Journal of Biomedical Science, 2011
Background A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model.
Karty Jonathan A, YoussefAgha Ahmed, Segu Zaneer M, Sari Youssef, Isailovic Dragan   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source