Results 51 to 60 of about 742,478 (265)

Comparative transcriptome analysis reveals a fetal origin for mesenchymal stem cells and novel fetal surface antigens for noninvasive prenatal diagnosis

Taiwanese Journal of Obstetrics & Gynecology, 2011
Objective: Mesenchymal stem cells (MSCs) are an attractive source for providing the cells necessary for regenerating damaged tissues. Fetal MSCs (fMSCs) are known to proliferate fast and have an excellent osteogenic capacity, yet the underlying ...
Shun-Long Weng, Shing-Jyh Chang, Yi-Chieh Cheng, Hua-Yong Wang, Tao-Yeuan Wang, Margaret Dah-Tsyr Chang, Hsei-Wei Wang   +6 more
doaj   +1 more source

Blood Plasma Proteins in Fetal Goats and Sheep.

Experimental Biology and Medicine, 1958
SummaryElectrophoretic separation of fetal and maternal plasma proteins in goats and sheep revealed that the fetal plasma lacks γ-globulins and exhibits an additional peak in the area of α1-globulins. This peak probably corresponds to fetuin. Quantitative conditions of fetal plasma proteins seem to depend largely on age of the fetus.
J J, BARBORIAK, G, MESCHIA, D H, BARRON, G R, COWGILL   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation

The EMBO Journal
Prenatal SARS-CoV-2 infection is associated with higher rates of pregnancy and birth complications, despite that vertical transmission rates are thought to be low.
Tamiris Azamor, Débora Familiar-Macedo, Gielenny M Salem, Chineme Onwubueke, Ivonne Melano, Lu Bian, Zilton Vasconcelos, Karin Nielsen-Saines, Xianfang Wu, Jae U Jung, Feng Lin, Oluwatosin Goje, Edward Chien, Steve Gordon, Charles B Foster, Hany Aly, Ruth M Farrell, Weiqiang Chen, Suan-Sin Foo   +18 more
doaj   +1 more source

BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands

Brazilian Oral Research
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second ...
Daniel Berretta Moreira ALVES, Lynne BINGLE, Colin David BINGLE, Silvia Vanessa LOURENÇO, Andréia Aparecida SILVA, Débora Lima PEREIRA, Pablo Agustin VARGAS   +6 more
doaj   +1 more source

Comparative Proteomic Profile of the Human Placenta in Normal and Fetal Growth Restriction Subjects

Cellular Physiology and Biochemistry, 2014
Background: Fetal growth restriction (FGR) is the main cause of intrauterine fetal death and the second leading cause of death in the neonatal period. A large body of evidence suggests that FGR may be associated with the placenta, although its etiology ...
Zhijing Miao, Min Chen, Hong Wu, Hongjuan Ding, Zhonghua Shi   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome

Journal of Immunology Research, 2016
Imbalance in the metabolites levels which can potentially be related to certain fetal chromosomal abnormalities can stimulate mother’s immune response to produce autoantibodies directed against proteins.
Karol Charkiewicz, Monika Zbucka-Kretowska, Joanna Goscik, Slawomir Wolczynski, Adam Lemancewicz, Piotr Laudanski   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source