Results 71 to 80 of about 2,560,680 (304)

Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation

The EMBO Journal
Prenatal SARS-CoV-2 infection is associated with higher rates of pregnancy and birth complications, despite that vertical transmission rates are thought to be low.
Tamiris Azamor, Débora Familiar-Macedo, Gielenny M Salem, Chineme Onwubueke, Ivonne Melano, Lu Bian, Zilton Vasconcelos, Karin Nielsen-Saines, Xianfang Wu, Jae U Jung, Feng Lin, Oluwatosin Goje, Edward Chien, Steve Gordon, Charles B Foster, Hany Aly, Ruth M Farrell, Weiqiang Chen, Suan-Sin Foo   +18 more
doaj   +1 more source

The characterization of preterm newborn saliva by top-down proteomic as a stimulus for the study of human development. A review of the results obtained over the past 25 years

Journal of Pediatric and Neonatal Individualized Medicine
Around the first years of 2000, our teams, at the Cagliari and Catholic-Policlinico Gemelli (Rome) Universities, started an investigation of the in­tact proteins of human saliva by a top-down pipeline.
Tiziana Cabras, Barbara Manconi, Alessandra Olianas, Maria Teresa Sanna, Cristina Contini, Giulia Guadalupi, Antonella Fiorita, Lea Calò, Gaetano Paludetti, Emanuele Scarano, Chiara Tirone, Giovanni Vento, Simona Fattore, Nicoletta Menzella, Davide De Tomaso, Federica Iavarone, Irene Messana, Claudia Desiderio, Diana Valeria Rossetti, Matteo Fraschini, Vassilios Fanos, Jacopo Galli, Gavino Faa, Massimo Castagnola   +23 more
doaj   +1 more source

Comparative transcriptome analysis reveals a fetal origin for mesenchymal stem cells and novel fetal surface antigens for noninvasive prenatal diagnosis

Taiwanese Journal of Obstetrics & Gynecology, 2011
Objective: Mesenchymal stem cells (MSCs) are an attractive source for providing the cells necessary for regenerating damaged tissues. Fetal MSCs (fMSCs) are known to proliferate fast and have an excellent osteogenic capacity, yet the underlying ...
Shun-Long Weng, Shing-Jyh Chang, Yi-Chieh Cheng, Hua-Yong Wang, Tao-Yeuan Wang, Margaret Dah-Tsyr Chang, Hsei-Wei Wang   +6 more
doaj   +1 more source

SERUM GLYCOSYLATED PROTEINS (GP): PREDICTORS OF MATERNAL-FETAL HYPERGLYCEMIA AND FETAL B.WT.? [PDF]

Pediatric Research, 1987
The usefulness of serum GP in detection of subtle hyperglycemia was studied in 3 groups of mother/infant pairs: 20 normal/20 AGA(GrI): 20 normal/20 MACRO, > 4.0kg (GrIII) and 9 diabetic mothers/10 neonates (GrIII). Two diabetics were class A, 4 class B and 3 class C. Maternal serum HbA1c and GP and cord GP were measured at delivery.
Geeti Ghosh, R S Pildes, Samuel Richton
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele [PDF]

, 2005
Myelomeningocele (MMC), the most severe form of spina bifida (SB), causes neurological deficit. Injury to the spinal cord is thought to begin in utero. We investigated whether brain-specific proteins (BSPs) would enable us to monitor the development of ...
Stiefel, D, Copp, AJ, Petzold, A
core  

Deregulated protein homeostasis constrains fetal hematopoietic stem cell pool expansion in Fanconi anemia

Nature Communications
Demand-adjusted and cell type specific rates of protein synthesis represent an important safeguard for fate and function of long-term hematopoietic stem cells.
Narasaiah Kovuru, Makiko Mochizuki-Kashio, Theresa Menna, Greer Jeffrey, Yuning Hong, Young me Yoon, Zhe Zhang, Peter Kurre   +7 more
doaj   +1 more source

Comparative Proteomic Profile of the Human Placenta in Normal and Fetal Growth Restriction Subjects

Cellular Physiology and Biochemistry, 2014
Background: Fetal growth restriction (FGR) is the main cause of intrauterine fetal death and the second leading cause of death in the neonatal period. A large body of evidence suggests that FGR may be associated with the placenta, although its etiology ...
Zhijing Miao, Min Chen, Hong Wu, Hongjuan Ding, Zhonghua Shi   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands

Brazilian Oral Research
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second ...
Daniel Berretta Moreira ALVES, Lynne BINGLE, Colin David BINGLE, Silvia Vanessa LOURENÇO, Andréia Aparecida SILVA, Débora Lima PEREIRA, Pablo Agustin VARGAS   +6 more
doaj   +1 more source