Results 61 to 70 of about 1,031,554 (306)

Proteomic profiling of human amnion for preterm birth biomarker discovery

Scientific Reports, 2021
Spontaneous preterm birth (PTB) complicates about 12% of pregnancies worldwide, remaining the main cause of neonatal morbidity and mortality. Spontaneous preterm birth PTBs is often caused by microbial-induced preterm labor, mediated by an inflammatory ...
Maurizio Bruschi, Martina Bartolucci, Andrea Petretto, Francesca Buffelli, Xhuliana Kajana, Alessandro Parodi, Riccardo Carbone, Ezio Fulcheri, Luca Antonio Ramenghi, Isabella Panfoli, Giovanni Candiano   +10 more
doaj   +1 more source

Prolactin Expression in the Baboon (Papio hamadryas) Eye

Animals, 2022
Prolactin (PRL) is a hormone expressed in lactotrophs cells of the pituitary gland in primates. Extra pituitary expression of PRL has been reported, including the eye; however, expression in the developing eye of primates is limited. The aim of the study
María Lourdes Garza-Rodríguez, Iram Pablo Rodríguez-Sanchez, Rafael González-Álvarez, Maricela Luna, Carlos Horacio Burciaga-Flores, Fernando Alcorta-Nuñez, Orlando Solis-Coronado, Víctor Manuel Bautista de Lucio, Genaro A. Ramírez-Correa, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave   +10 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Human Cytomegalovirus Dysregulates Cellular Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases and Sonic Hedgehog Pathway Proteins in Neural Astrocyte and Placental Models

Viruses
Human cytomegalovirus (CMV) infection is the leading non-genetic cause of congenital malformation in developed countries, causing significant fetal injury, and in some cases fetal death.
Ece Egilmezer, Stuart T. Hamilton, Glen Lauw, Jasmine Follett, Eric Sonntag, Martin Schütz, Manfred Marschall, William D. Rawlinson   +7 more
doaj   +1 more source

cDNA Cloning Demonstrates the Expression of Pregnancy-Specific Glycoprotein Genes, a Subgroup of the Carcinoembryonic Antigen Gene Family, in Fetal Liver [PDF]

, 1989
The pregnancy-specific glycoprotein (PSG) genes constitute a subgroup of the carcinoembryonic antigen (CEA) gene family. Here we report the cloning of four cDNAs coding for different members of the PSG family from a human fetal liver cDNA library.
Thompson, John A., Weiss, Martina, Zimmermann, Wolfgang   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation

The EMBO Journal
Prenatal SARS-CoV-2 infection is associated with higher rates of pregnancy and birth complications, despite that vertical transmission rates are thought to be low.
Tamiris Azamor, Débora Familiar-Macedo, Gielenny M Salem, Chineme Onwubueke, Ivonne Melano, Lu Bian, Zilton Vasconcelos, Karin Nielsen-Saines, Xianfang Wu, Jae U Jung, Feng Lin, Oluwatosin Goje, Edward Chien, Steve Gordon, Charles B Foster, Hany Aly, Ruth M Farrell, Weiqiang Chen, Suan-Sin Foo   +18 more
doaj   +1 more source

The characterization of preterm newborn saliva by top-down proteomic as a stimulus for the study of human development. A review of the results obtained over the past 25 years

Journal of Pediatric and Neonatal Individualized Medicine
Around the first years of 2000, our teams, at the Cagliari and Catholic-Policlinico Gemelli (Rome) Universities, started an investigation of the in­tact proteins of human saliva by a top-down pipeline.
Tiziana Cabras, Barbara Manconi, Alessandra Olianas, Maria Teresa Sanna, Cristina Contini, Giulia Guadalupi, Antonella Fiorita, Lea Calò, Gaetano Paludetti, Emanuele Scarano, Chiara Tirone, Giovanni Vento, Simona Fattore, Nicoletta Menzella, Davide De Tomaso, Federica Iavarone, Irene Messana, Claudia Desiderio, Diana Valeria Rossetti, Matteo Fraschini, Vassilios Fanos, Jacopo Galli, Gavino Faa, Massimo Castagnola   +23 more
doaj   +1 more source

Comparative transcriptome analysis reveals a fetal origin for mesenchymal stem cells and novel fetal surface antigens for noninvasive prenatal diagnosis

Taiwanese Journal of Obstetrics & Gynecology, 2011
Objective: Mesenchymal stem cells (MSCs) are an attractive source for providing the cells necessary for regenerating damaged tissues. Fetal MSCs (fMSCs) are known to proliferate fast and have an excellent osteogenic capacity, yet the underlying ...
Shun-Long Weng, Shing-Jyh Chang, Yi-Chieh Cheng, Hua-Yong Wang, Tao-Yeuan Wang, Margaret Dah-Tsyr Chang, Hsei-Wei Wang   +6 more
doaj   +1 more source

Prevalence, sensitivity and specificity of antibodies against carbamylated proteins in a monocentric cohort of patients with rheumatoid arthritis and other autoimmune rheumatic diseases [PDF]

, 2016
Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity and specificity of anti-CarP compared to ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Mancini, Riccardo, Morello, Francesca, Pecani, Arbi, Pendolino, Monica, Priori, Roberta, Riccieri, Valeria, Sabatinelli, Danilo, Spinelli, FRANCESCA ROMANA, Truglia, Simona, Valesini, Guido, Vomero, Marta   +16 more
core   +1 more source