Results 31 to 40 of about 742,478 (265)

Microanatomy of the enteric neurons and glia; expression patterns of the PGP9.5, S100b proteins, RET and SOX10 genes in the human fetal gut wall

Translational Research in Anatomy
Background: Enteric nervous system comprises enteric neurons and glia, derived from neural crest cells, and regulates the gastrointestinal function. Previous animal studies have highlighted the essential roles of RET and SOX10 genes, along with PGP9.5 ...
Chacchu Bhattarai, Phanindra Prasad Poudel, Arnab Ghosh, Saman Man Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, Vani Lakshmi R, Sujan Gautam, Sneha Guruprasad Kalthur   +11 more
doaj   +1 more source

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. [PDF]

PLoS ONE, 2011
The uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty
Takuya Mishima, Jeffrey H Miner, Mayumi Morizane, Andreas Stahl, Yoel Sadovsky   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey

Nature Communications, 2023
Fetal stages are critical periods for brain development. However, the protein molecular signature and dynamics of the human brain remain unclear due to sampling difficulty and ethical limitations.
Jingkuan Wei, Shaoxing Dai, Yaping Yan, Shulin Li, Pengpeng Yang, Ran Zhu, Tianzhuang Huang, Xi Li, Yanchao Duan, Zhengbo Wang, Weizhi Ji, Wei Si   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A cross-sectional examination of immune adaptations during pregnancy in the ECHO Cohort

Frontiers in Immunology
BackgroundPregnancy requires finely tuned immune changes that support implantation, placental development, maternal–fetal tolerance, and preparation for labor, yet the normative trajectories of circulating inflammatory proteins across gestation remain ...
Sarah M. Banker, Rosa Shapiro-Thompson, Sarah Sinsel, Akhgar Ghassabian, Christian Douglas, Morgan E. Nelson, Lisa A. Peterson, Bharat Thyagarajan, Santiago Morales, Christine W. Hockett, Christine W. Hockett, Amy J. Elliott, Amy J. Elliott, Stephanie N. Giamberardino, Lauren C. Shuffrey   +14 more
doaj   +1 more source

Screening circulating proteins to identify biomarkers of fetal macrosomia

BMC Research Notes, 2019
Objective Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal traumatic injuries, and perinatal death.
Tess Cruickshank, Tu’uhevaha J. Kaitu’u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M. Dane, Anna L. Middleton, Valerie P. Kyritsis, Roxanne Hastie, Stephen Tong, Susan P. Walker, Teresa M. MacDonald   +11 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Neuroprotective peptide ADNF-9 in fetal brain of C57BL/6 mice exposed prenatally to alcohol

Journal of Biomedical Science, 2011
Background A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model.
Karty Jonathan A, YoussefAgha Ahmed, Segu Zaneer M, Sari Youssef, Isailovic Dragan   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source