Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy. [PDF]
Fetal Diagn Ther, 2019 Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral ...
Fontanella F +9 more
europepmc +3 more sources
Pulmonary Hypoplasia Caused by Fetal Ascites in Congenital Cytomegalovirus Infection Despite Fetal Therapy [PDF]
Frontiers in Pediatrics, 2017 We report two cases of pulmonary hypoplasia due to fetal ascites in symptomatic congenital cytomegalovirus (CMV) infections despite fetal therapy. The patients died soon after birth. The pathogenesis of pulmonary hypoplasia in our cases might be thoracic
Kazumichi Fujioka +7 more
doaj +3 more sources
Care Levels for Fetal Therapy Centers. [PDF]
Obstet Gynecol, 2022 Fetal therapies undertaken to improve fetal outcome or to optimize transition to neonate life often entail some level of maternal, fetal, or neonatal risk.
Baschat AA +22 more
europepmc +2 more sources
Investigating attitudes toward prenatal diagnosis and fetal therapy for spinal muscular atrophy. [PDF]
Prenat Diagn, 2022 In utero SMA treatment could improve survival and neurologic outcomes. We investigated the attitudes of patients and parents with SMA regarding prenatal diagnosis, fetal therapies, and clinical trials.
Schwab ME +8 more
europepmc +2 more sources
A new ethical framework to determine acceptable risks in fetal therapy trials. [PDF]
Prenat Diagn, 2022 Fetal therapy trials pose complex ethical challenges because risks and benefits to both fetuses and pregnant persons must be considered. Existing regulatory guidance is limited and many proposed ethical frameworks have unnecessarily restrictive criteria ...
Hendriks S +5 more
europepmc +2 more sources
JAMA, 2023 Importance Early anhydramnios during pregnancy, resulting from fetal bilateral renal agenesis, causes lethal pulmonary hypoplasia in neonates.
Miller JL +22 more
europepmc +2 more sources
A New Ethical Framework for Assessing the Unique Challenges of Fetal Therapy Trials. [PDF]
Am J Bioeth, 2022 New fetal therapies offer important prospects for improving health. However, having to consider both the fetus and the pregnant woman makes the risk–benefit analysis of fetal therapy trials challenging.
Hendriks S +5 more
europepmc +2 more sources
Trends in research related to fetal therapy from 2012 to 2022: a bibliometric analysis [PDF]
Frontiers in Pediatrics, 2023 BackgroundThe development of prenatal diagnosis technology allows prompt detection of severe fetal diseases. To address adverse factors that threaten fetal survival, fetal therapy came into existence, which aims to preserve the function after birth to a ...
Yang Jia +8 more
doaj +2 more sources
The TOTAL trial dilemma: A survey among professionals on equipoise regarding fetal therapy for severe congenital diaphragmatic hernia. [PDF]
Prenat Diagn, 2021 Running randomized clinical trials (RCT) in fetal therapy is challenging. This is no different for fetoscopic endoluminal tracheal occlusion (FETO) for severe left‐sided Congenital Diaphragmatic Hernia (CDH).
Vergote S +5 more
europepmc +2 more sources
Prenatal Diagnosis of Fetal Aqueductal Stenosis: A Multicenter Prospective Observational Study through the North American Fetal Therapy Network. [PDF]
Fetal Diagn TherIntroduction: A critical component of an evidence-based reassessment of in-utero intervention for fetal aqueductal stenosis (fetal AS) is determining if the prenatal diagnosis can be accurately made at a gestational age amenable to in-utero intervention.
Emery SP +11 more
europepmc +2 more sources