Results 21 to 30 of about 5,593,834 (345)

Autologous bone marrow-derived MSCs engineered to express oFVIII-FLAG engraft in adult sheep and produce an effective increase in plasma FVIII levels

open access: yesFrontiers in Immunology, 2022
IntroductionHemophilia A (HA) is the most common X-linked bleeding disorder, occurring in 1 in 5,000 live male births and affecting >1 million individuals worldwide.
Brady Trevisan   +8 more
doaj   +1 more source

Fetal therapies as standard prenatal care in Japan [PDF]

open access: yesObstetrics & Gynecology Science, 2020
With recent advances in fetal medicine, various attempts have been made to save fetuses facing perinatal death or devastating consequences despite optimal management after birth.
Haruhiko Sago, Seiji Wada
doaj   +1 more source

Perinatal Gene Transfer to the Liver [PDF]

open access: yes, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM   +6 more
core   +1 more source

Repeat epidural blood patch at the level of unintentional dural puncture and its neurologic complications: a case report

open access: yesJA Clinical Reports, 2019
Background Autologous epidural blood patch (AEBP) is effective for post-dural-puncture headache (PDPH). In some cases, repeat procedures are required for complete cure. In rare instances, severe adverse effects can occur.
Kentaro Iga   +9 more
doaj   +1 more source

Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity

open access: yesNature Communications, 2023
Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII levels 3 years post-treatment.
Martin Rodriguez   +16 more
doaj   +1 more source

Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery

open access: yesMolecular Therapy: Methods & Clinical Development, 2020
Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when combined, make them ideally suited for cellular-based immunotherapy and as vehicles for gene and drug delivery for a wide range of diseases and disorders.
Graça Almeida-Porada   +2 more
doaj   +1 more source

Application of a postnatal prediction model of survival in CDH in the era of fetal therapy

open access: yesJournal of Maternal-Fetal & Neonatal Medicine, 2020
Background: The disease severity in patients with a congenital diaphragmatic hernia (CDH) is highly variable. To compare patient outcomes, set up clinical trials and come to severity-based treatment guidelines, a performant prediction tool early in ...
K. Clohse   +5 more
semanticscholar   +1 more source

Low-carbohydrate diets for gestational diabetes [PDF]

open access: yes, 2019
Nutrition therapy provides the foundation for treatment of gestational diabetes (GDM), and has historically been based on restricting carbohydrate (CHO) intake. In this paper, randomized controlled trials (RCTs) are reviewed to assess the effects of both
Farabi, Sarah S, Hernandez, Teri L
core   +2 more sources

Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status [PDF]

open access: yes, 2020
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular.
Barber, Thomas M.   +2 more
core   +1 more source

Uterine Rupture at 21 Weeks in Twin Pregnancy with TTTS and Previous C-Section

open access: yesCase Reports in Obstetrics and Gynecology, 2017
Uterine rupture is a health problem in every country. The diagnosis is not always obvious and fetal and maternal morbidity and mortality can be high.
Gieta Bhikha-kori   +2 more
doaj   +1 more source

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