Results 51 to 60 of about 359,252 (255)

Establishment, characterization and cryopreservation of Fars native goat fetal fibroblast cell lines

Asian Pacific Journal of Reproduction, 2016
Objective: To biologically develop and evaluate the caprine fetal fibroblast cell cultures before and after freezing. Methods: Goat fetuses (ages 51, 53 and 55 d) were collected from slaughterhouse.
Davood Mehrabani, Marzieh Tajedini, Amin Tamadon, Mehdi Dianatpour, Fatemeh Parvin, Shahrokh Zare, Farhad Rahmanifar   +6 more
doaj   +1 more source

The Viability of a Tool for Fetal Health Monitoring

, 2016
Abstract: Health monitoring has become widespread these past few years. Such applicationsinclude from exercise, food intake and weight watching, to specific scenarios like monitoringpeople who suffer from chronic diseases. More and more we see the need to also monitorthe health of new-born babies and even fetuses.
Bardhi, Ornela, Hallberg, Josef
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Survey of the Definition of Fetal Viability and the Availability, Indications, and Decision Making Processes for Post‐Viability Termination of Pregnancy for Fetal Abnormalities and Health Conditions in Canada [PDF]

Journal of Genetic Counseling, 2015
AbstractThe purpose of this study was to explore the definition of fetal viability and the availability, indications, and decision making processes for post‐viability termination of pregnancy for fetal abnormalities and health conditions in Canada. An online survey of members of the Canadian Association of Genetic Counsellors, the Canadian College of ...
Danna, Hull, Gregory, Davies, Christine M, Armour   +2 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Surgical alteration of uterine space influences embryonic loss and fetal growth in the contemporary pig

BMC Veterinary Research
Background Litter size is a key economic trait in the swine industry, and ongoing selection for this trait has increased ovulation rates without producing a corresponding increase in uterine capacity. Overcrowding, intensifies competition between fetuses,
Dayeon Jeon, Alyssa A. Smith, Sarah Innis, Bea Cabot, Ryan Cabot, Jonathan Alex Pasternak   +5 more
doaj   +1 more source

Physiological response to hypoxia in piglets of different birth weight

Italian Journal of Animal Science, 2011
In the present study, we aimed to extend the characterization of the proposed naturalistic experimental model of piglets born with hypoxia by assessing the relationship between birth weight, intra partum asphyxia and gross indicators of ...
Ramiro Ramírez-Necoechea, Ana Rosales-Torres, María Alonso-Spilsbury, Patricia Mora-Medina, Patricia Roldan-Santiago, Rafael Hernández-González, Héctor Orozco-Gregorio, María E. Trujillo-Ortega, Daniel Mota-Rojas, Roberto Martínez-Rodríguez   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source