Results 71 to 80 of about 516,032 (299)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. [PDF]

, 1984
The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).
Donaldson, CA, Haussler, MR, Haussler, MR, Koeffler, HP, Mangelsdorf, DJ, Pike, JW   +5 more
core   +1 more source

The Viability of a Tool for Fetal Health Monitoring

, 2016
Abstract: Health monitoring has become widespread these past few years. Such applicationsinclude from exercise, food intake and weight watching, to specific scenarios like monitoringpeople who suffer from chronic diseases. More and more we see the need to also monitorthe health of new-born babies and even fetuses.
Bardhi, Ornela, Hallberg, Josef
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Surgical alteration of uterine space influences embryonic loss and fetal growth in the contemporary pig

BMC Veterinary Research
Background Litter size is a key economic trait in the swine industry, and ongoing selection for this trait has increased ovulation rates without producing a corresponding increase in uterine capacity. Overcrowding, intensifies competition between fetuses,
Dayeon Jeon, Alyssa A. Smith, Sarah Innis, Bea Cabot, Ryan Cabot, Jonathan Alex Pasternak   +5 more
doaj   +1 more source

Survey of the Definition of Fetal Viability and the Availability, Indications, and Decision Making Processes for Post‐Viability Termination of Pregnancy for Fetal Abnormalities and Health Conditions in Canada [PDF]

Journal of Genetic Counseling, 2015
AbstractThe purpose of this study was to explore the definition of fetal viability and the availability, indications, and decision making processes for post‐viability termination of pregnancy for fetal abnormalities and health conditions in Canada. An online survey of members of the Canadian Association of Genetic Counsellors, the Canadian College of ...
Danna, Hull, Gregory, Davies, Christine M, Armour   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Physiological response to hypoxia in piglets of different birth weight

Italian Journal of Animal Science, 2011
In the present study, we aimed to extend the characterization of the proposed naturalistic experimental model of piglets born with hypoxia by assessing the relationship between birth weight, intra partum asphyxia and gross indicators of ...
Ramiro Ramírez-Necoechea, Ana Rosales-Torres, María Alonso-Spilsbury, Patricia Mora-Medina, Patricia Roldan-Santiago, Rafael Hernández-González, Héctor Orozco-Gregorio, María E. Trujillo-Ortega, Daniel Mota-Rojas, Roberto Martínez-Rodríguez   +9 more
doaj   +1 more source

“Avoiding the battle or deliberately opaque? Fair labelling and accessible language in the abortion debate”. [PDF]

, 2014
A visual presentation of the outmoded, frequently opaque and confusing language used in abortion regulation, professional guidance, related literature and debate.
Wale, Jeffrey
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source