Results 31 to 40 of about 476,830 (314)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fetal ultrasound estimated weight and correlation to Brazilian newborn weight

Journal of Ultrasonography, 2020
Background: To compare the best fetal weight formula with different biometric tables on the weight of Brazilian newborns. Methods: This observational study has tested the performance of different common fetal weight formulas and biometric tables.
Galluzzo Roberto Noya, Trapani Alberto, Werner Heron, de Sá Renato Augusto Moreira, Xikota João Carlos, Araujo Edward, de Souza Pires Maria Marlene   +6 more
doaj   +1 more source

Ultrasound measurement of umbilical vein diameter in normal pregnancy and correlation with gestational age and fetal weight

Nigerian Journal of Medicine, 2022
Background: With the invention of more sophisticated ultrasonography techniques, there is room to explore and better comprehend the link between gestational age (GA), fetal weight (FW), and the diameter of the umbilical vein (UV).
Peter Chibuzor Oriji, Enefia Kelvin Kiridi, Chioma Okechukwu, Akaninyene Eseme Ubom, Datonye Christopher Briggs, Johnpatrick Uchenna Ugwoegbu, Panebi Yao Bosrotsi, Abednigo Ojanerohan Addah, Isaac Joel Abasi, Adedotun Daniel Adesina   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Acurácia da estimativa ultrassonográfica do peso fetal e influência de fatores maternos e fetais Ultrasonographic accuracy of fetal weight estimation and influence of maternal and fetal factors

Revista Brasileira de Ginecologia e Obstetrícia, 2011
OBJETIVO: Avaliar a eficácia da estimativa ultrassonográfica na predição do peso fetal e analisar fatores maternos e/ou fetais que interferem no resultado.
Aline Giroto Ricci, Maria de Lourdes Brizot, Adolfo Wenjaw Liao, Roseli Mieko Yamamoto Nomura, Marcelo Zugaib   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Estimation of Fetal Birth Weight Using Ultra Sonographic Parameters

Journal of Nepal Medical Association, 2013
One hundred antenatal patients were studied at term pregnancy at Gauhati Medical College, Guwahati, and fetal birth weight estimation was done in utero Ultrasono-graphically. The parameters measured were Abdominal Circumference (AC), Biparietal diameter (
Kaveeta Dawaka, G C Das
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

FETAL DISCORDANCY IN MONOCHORIONIC TWINS

Акушерство, гинекология и репродукция, 2016
Objective: to investigate the predictive value of fetal weight discordance as a risk factor associated with adverse perinatal outcomes. Materials and Methods: 55 patients with monochorionic diamniotic twin pregnancies with fetal weight discordancy were ...
L. G. Sichinava, O. B. Panina, K. G. Gamsakhurdiya   +2 more
doaj   +1 more source