Results 61 to 70 of about 4,656,954 (331)
Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal study [PDF]
, 2014 OBJECTIVES: Transgenerational effects of different environmental exposures are of major interest, with rodent experiments focusing on epigenetic mechanisms. Previously, we have shown that if the study mother is a non-smoker, there is increased mean birth Golding, Jean, Gregory, Steven, Miller, Laura L, Northstone, Kate, Pembrey, Marcus +4 morecore +2 more sourcesPARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer +21 morewiley +1 more sourceFetal and infant growth and the risk of obesity during early childhood: the Generation R Study. [PDF]
, 2011 OBJECTIVE: To examine whether infant growth rates are influenced by fetal growth characteristics and are associated with the risks of overweight and obesity in early childhood. DESIGN: This study was embedded in the Generation R Study, a population-based Durmuş, Büşra, Hofman, Albert, Jaddoe, Vincent WV, Jarvelin, Marjo-Riitta, Mook-Kanamori, Dennis O, Raat, Hein, Sovio, Ulla, Steegers, Eric AP +7 morecore +1 more sourceInvestigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov +10 morewiley +1 more sourceMaternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Nature Genetics, 2018 Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes.N. Warrington, R. Beaumont, M. Horikoshi, F. Day, Ø. Helgeland, Ø. Helgeland, Ø. Helgeland, Charles Laurin, Charles Laurin, J. Bacelis, Shouneng Peng, K. Hao, B. Feenstra, A. Wood, A. Mahajan, Jessica Tyrrell, Jessica Tyrrell, N. Robertson, N. W. Rayner, Zhen Qiao, G. Moen, G. Moen, M. Vaudel, C. Marsit, Jia Chen, M. Nodzenski, T. Schnurr, M. Zafarmand, J. Bradfield, N. Grarup, Marjolein N. Kooijman, R. Li-Gao, F. Geller, T. Ahluwalia, L. Paternoster, R. Rueedi, R. Rueedi, V. Huikari, J. Hottenga, L. Lyytikäinen, A. Cavadino, A. Cavadino, S. Metrustry, D. Cousminer, D. Cousminer, Ying Wu, E. Thiering, Carol A. Wang, C. Have, N. Vilor-Tejedor, Peter K. Joshi, J. Painter, I. Ntalla, Ronny Myhre, N. Pitkänen, E. M. Leeuwen, R. Joro, V. Lagou, V. Lagou, R. Richmond, R. Richmond, Ana Espinosa, S. Barton, Hazel M. Inskip, Hazel M. Inskip, J. Holloway, L. Santa-Marina, X. Estivill, W. Ang, J. Marsh, C. Reichetzeder, L. Marullo, B. Hocher, K. Lunetta, J. Murabito, C. Relton, C. Relton, M. Kogevinas, L. Chatzi, Catherine Allard, Luigi Bouchard, Luigi Bouchard, M. Hivert, M. Hivert, Ge Zhang, Ge Zhang, Louis J. Muglia, Louis J. Muglia, Jani Heikkinen, C. S. Morgen, A. H. C. V. Kampen, A. H. C. V. Kampen, Barbera D. C. Schaik, F. Mentch, C. Langenberg, J. Luan, R. Scott, Jing Hua Zhao, G. Hemani, G. Hemani, S. Ring, S. Ring, A. Bennett, K. Gaulton, K. Gaulton, J. Fernández-Tajes, N. Zuydam, C. Medina-Gomez, H. G. D. Haan, F. Rosendaal, Zoltán Kutalik, Zoltán Kutalik, P. Marques-Vidal, Shikta Das, G. Willemsen, H. Mbarek, M. Müller-Nurasyid, M. Standl, E. V. Appel, C. Fonvig, C. Trier, Catharina E. M. van Beijsterveldt, Mario Murcia, Mario Murcia, Mariona Bustamante, Mariona Bustamante, S. Bonàs-Guarch, D. Hougaard, J. Mercader, J. Mercader, J. Mercader, A. Linneberg, Katharina E. Schraut, P. Lind, S. Medland, B. Shields, B. Knight, Jin-Fang Chai, K. Panoutsopoulou, M. Bartels, Friman Sánchez, J. Stokholm, D. Torrents, R. Vinding, Sara M. Willems, M. Atalay, B. Chawes, P. Kovacs, I. Prokopenko, I. Prokopenko, M. Tuke, H. Yaghootkar, K. Ruth, Samuel E. Jones, Po-Ru Loh, Po-Ru Loh, A. Murray, M. Weedon, A. Tönjes, M. Stumvoll, K. Michaelsen, Aino-Maija Eloranta, T. Lakka, C. Duijn, W. Kiess, A. Körner, H. Niinikoski, H. Niinikoski, K. Pahkala, Olli T Raitakari, Olli T Raitakari, B. Jacobsson, B. Jacobsson, E. Zeggini, G. Dedoussis, Y. Teo, S. Saw, G. Montgomery, H. Campbell, James F. Wilson, T. Vrijkotte, Martine Vrijheid, Martine Vrijheid, E. D. Geus, M. Hayes, H. Kadarmideen, J. Holm, L. Beilin, C. Pennell, Joachim Heinrich, L. Adair, J. Borja, K. Mohlke, J. Eriksson, J. Eriksson, E. Widén, A. Hattersley, A. Hattersley, T. Spector, M. Kähönen, J. Viikari, J. Viikari, T. Lehtimäki, D. Boomsma, S. Sebert, P. Vollenweider, T. I. Sørensen, T. I. Sørensen, H. Bisgaard, K. Bønnelykke, J. Murray, M. Melbye, E. Nøhr, D. Mook-Kanamori, F. Rivadeneira, A. Hofman, J. Felix, V. Jaddoe, T. Hansen, C. Pisinger, A. Vaag, O. Pedersen, A. Uitterlinden, M. Järvelin, C. Power, Elina Hyppönen, Elina Hyppönen, D. Scholtens, W. Lowe, George Davey Smith, George Davey Smith, N. Timpson, N. Timpson, Andrew P Morris, Andrew P Morris, Andrew P Morris, N. Wareham, H. Hakonarson, H. Hakonarson, S. Grant, T. Frayling, Debbie A. Lawlor, Debbie A. Lawlor, P. R. Njølstad, P. R. Njølstad, Stefan Johansson, Stefan Johansson, K. Ong, Mark I. McCarthy, Mark I. McCarthy, J. Perry, David Evans, David Evans, David Evans, R. Freathy, R. Freathy +255 moresemanticscholar +1 more sourcePYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu +13 morewiley +1 more source