Results 61 to 70 of about 2,766,339 (297)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Estimation of Fetal Weight by Clinical Methods and Ultrasonography and Comparing With Actual Birth Weight

Journal of Holistic Nursing and Midwifery, 2021
Introduction: Assessment of fetal weight is a vital factor in antenatal care, not only in the management of labor and delivery but also in identifying fetal weight disorders.
Raziyeh Mossayebnezhad, Maryam Niknami, Sedigheh Pakseresht, Ehsan Kazemnezhad Leili   +3 more
doaj  

Current knowledge on the use of ultrasound measurements of fetal soft tissues for the assessment of pregnancy development

Journal of Ultrasonography, 2018
Ultrasonography, with its detailed imaging of the fetus, is very widely used in obstetrics. The primary aim of ultrasound scanning in pregnancy is to limit the risk of obstetric complications by early detection of abnormalities, such as intrauterine ...
Aleksandra Warska, Anna Maliszewska, Anna Wnuk, Beata Szyszka, Włodzimierz Sawicki, Krzysztof Cendrowski   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development [PDF]

, 2012
Among primates, human neonates have the largest brains but also the highest proportion of body fat. If placental nutrient supply is limited, the fetus faces a dilemma: should resources be allocated to brain growth, or to fat deposition for use as a ...
Crozier, SR, Sarah R. Crozier, Sian M. Robinson, Guttorm Haugen (141243), Sarah R Crozier, Kiserud, T., Hanson, M.A., Inskip, H.M., Haugen Guttorm, Nicholas C. W. Harvey, Harvey Nicholas C. W., Crozier Sarah R., Haugen, G., Hazel M. Inskip, Robinson Sian M., Crozier, S.R., Inskip, HM, Mark A. Hanson (114427), Cyrus Cooper (141250), Godfrey, Keith M., Sian M Robinson, Mark A Hanson, Cyrus Cooper, Cooper Cyrus, Lucy Davies, Harvey, NC, Hazel M. Inskip (141248), Haugen, G, Guttorm Haugen, Harvey, N.C., Godfrey Keith M., Kiserud, T, Robinson, S.M., Mark A. Hanson, Keith M Godfrey, Nicholas C W Harvey, Hanson Mark A., Torvid Kiserud, Southampton Women's Survey Study Group, Cooper, Cyrus, Davies, L, Hanson, MA, Sarah R. Crozier (141254), Keith M. Godfrey, Inskip Hazel M., Godfrey, KM, Hazel M Inskip, Sian M. Robinson (141258), Kiserud Torvid, Keith M. Godfrey (141238), Cooper, C., Robinson, SM, Davies Lucy, Cooper, C, Torvid Kiserud (141246), Lucy Davies (141261), Davies, L., Nicholas C. W. Harvey (141252)   +57 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Analysis of factors influencing accuracy of ultrasound-based fetal weight estimation

Indian Journal of Radiology and Imaging, 2020
Context: The primary objective of this study was to examine the impact of maternal age, parity, gestational age, fetal gender, gestational diabetes mellitus, and pregnancy-induced hypertension on the accuracy of ultrasonography-based fetal weight ...
Sujitkumar Hiwale, Celine Firtion
doaj   +1 more source