Results 61 to 70 of about 225,033 (309)

Innovative integration of automated breast volume scan and ultrasound elastography for enhanced differentiation of benign and malignant breast lesions

Scientific Reports
Breast cancer remains the most common malignancy among women and a leading cause of cancer-related mortality worldwide. Early detection through imaging is critical for improving patient prognosis.
Lamei Zhang, Yao Peng, Yang He, Zixian Wei, Ling Gan, Jiaqi Zhang   +5 more
doaj   +1 more source

Pathologic anatomy of the fetus from mothers with complicated pregnancy

Patologìâ, 2012
The article describes the morphological changes in the heart, testes, bone marrow, thymus, spleen of fetuses from mothers with complicated pregnancy.
A.F. Yakovtsova, V.D. Markovskiy, I.V. Sorokina, G.I. Gubina-Vakulik, V.V. Gargin, O.A. Omelchenko, M.S. Myroshnichenko, D.I. Galata, S.N. Potapov, A.S. Shapkin   +9 more
doaj   +1 more source

Management of fetuses with apparent normal growth and abnormal cerebroplacental ratio: A risk‐based approach near term [PDF]

, 2023
José Morales-­Roselló­, Asma Khalil, Alicia Martínez‐Varea   +2 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Intravenous Immune Globulin Uses in the Fetus and Neonate: A Review [PDF]

, 2020
Mahdi Alsaleem
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Maternal Influenza A Virus Infection Restricts Fetal and Placental Growth and Adversely Affects the Fetal Thymic Transcriptome

Viruses, 2020
Maternal influenza A viral infections in humans are associated with low birth weight, increased risk of pre-term birth, stillbirth and congenital defects. To examine the effect of maternal influenza virus infection on placental and fetal growth, pregnant
Hana Van Campen, Jeanette V. Bishop, Vikki M. Abrahams, Helle Bielefeldt-Ohmann, Candace K. Mathiason, Gerrit J. Bouma, Quinton A. Winger, Christie E. Mayo, Richard A. Bowen, Thomas R. Hansen   +9 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

In Utero Brain Growth Matters for Fetuses With Congenital Heart Disease [PDF]

, 2022
Mike Seed, Catherine Limperopoulos
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source