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Fever of unknown origin is a rare clinical syndrome, that represents a significant diagnostic challenge. There have been described more than 200 potential diseases, that can manifest as a fever of unknown origin. These are classically divided into following categories: infections, non-infectious inflammatory diseases, malignancies, and other ...
Vyacheslav, Grebenyuk +11 more
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Fever of unknown origin. A changing clinical spectrum and a diagnostic challenge
This issue of Case Reports presents two cases of fever of unknown origin (FUO) that illustrate the etiological diversity and diagnostic complexity of this condition.
Moisés Casarrubias-Ramírez
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More than 50 years after the first definition of fever of unknown origin (FUO), it still remains a diagnostic challenge. Evaluation starts with the identification of potential diagnostic clues (PDCs), which should guide further investigations. In the absence of PDCs a standardised diagnostic protocol should be followed with PET-CT as the imaging ...
Mulders-Manders, C. +2 more
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Idiopathic Polyclonal Plasmacytosis Presenting as Fever of Unknown Origin
An elderly male, after being flagged to have fever of unknown origin, was found to have plasmacytosis on bone marrow examination. On immunophenotyping, the proliferation was confirmed as polyclonal. No associated underlying condition such as infection or
Vivek Pal Singh, Ashutosh Garg
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Fever of unknown origin (FUO) often is defined as a fever greater than 38.3 degrees C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory tests. In general, infection accounts for approximately one-fourth of cases of FUO, followed by neoplasm and noninfectious inflammatory diseases. No diagnosis is reached
Bleeker-Rovers, C.P. +2 more
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Diagnostic Use of Serum Ferritin Levels to Differentiate Infectious and Noninfectious Diseases in Patients with Fever of Unknown Origin [PDF]
Background and study aim: Fever of unknown origin (FUO) constitutes one of the greatest challenges of clinical practice. It's defined as fever more than three weeks with fever above 38.3ºC on several occasions which remains undiagnosed after 3 days of ...
Rania Sobh +2 more
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An 18-year-old male was admitted for his second induction chemotherapy treatment for an acute lymphoblastic leukaemia with cyclophosphamide, cytarabine, and mercaptopurine.
Ignacio Martín Santarelli +6 more
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Hemophagocytic lymphohistiocytosis (HLH) is a rare and life‐threatening clinical syndrome, which may present with FUO. The possible diagnosis of HLH must be considered in the differential diagnosis when a patient presents with FUO.
Atousa Hakamifard +2 more
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Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center [PDF]
PurposeFever is one of the most common symptoms in children. In previous studies, infectious disease was the most common cause of pediatric fever of unknown origin (FUO).
Yi-Seul Kim +4 more
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