Results 121 to 130 of about 50,069 (263)

Adrenal hormones in the maintenance of glucose homeostasis during prolonged fasting in male glucagon‐deficient mice [PDF]

J Diabetes Investig
Compensatory corticosterone‐mediated lipolysis and hepatic gluconeogenesis (via amino acids and glycerol) prevent hypoglycemia in GCGKO mice during prolonged fasting. ABSTRACT Aims/Introduction Glucagon is a key regulator of fasting glucose homeostasis, but the contribution of adrenal hormones during prolonged fasting remains unclear.
Kanie S, Nishida K, Seino Y, Hidaka S, Ueno S, Sumioki H, Tomatsu E, Haraguchi T, Murao N, Fujisawa H, Takayanagi T, Sugimura Y, Hayashi Y, Suzuki A.   +13 more
europepmc   +2 more sources

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

FFA-SegGPT: A Two-Stage Cross-Modal AI System to Optimize the Clinical Workflow of Diabetic Retinopathy FFA Interpretation. [PDF]

Transl Vis Sci Technol
Gan F, Chen X, Shao Y, Li H, Chen W, Qin W, Long X, Fan H, Hu H, Yu Z, Chen K, Xu N, Chen L, Cao J, Li J, You Z.   +15 more
europepmc   +1 more source

Five‐Year Treatment Outcomes of Macular Oedema Secondary to Central Retinal Vein Occlusion in Routine Clinical Practice: The Fight Retinal Blindness! Registry

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To report 5‐year outcomes in a cohort of patients who received anti‐VEGF therapy for macular oedema secondary to central retinal vein occlusion (CRVO) in routine clinical practice. Methods In this retrospective observational study, 593 treatment‐naïve eyes that commenced anti‐VEGF treatment between 1 January 2010, and 2019 were ...
Katrin Rudolph, Marianna Rosso, Mark Gillies, Adrian Hunt, Louise O'Toole, Alessandro Invernizzi, David Squirrell, Hemal Mehta, Richard Barry, Pierre‐Henry Gabrielle, Daniel Barthelmes   +10 more
wiley   +1 more source

Acyl transfer activity inhibition and its application in moderate enzymatic degumming of crude soybean oil. [PDF]

Food Chem X
Guo R, Du X, Luo S, Wang L, Yang F, Yu D.   +5 more
europepmc   +1 more source

Evaluation of the Safety and Therapeutic Range of Nanosecond Laser Treatment in Rabbits

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Subthreshold, nanosecond laser therapy has potential as a treatment for age‐related macular degeneration; however, the therapeutic range and safety profile have not been fully documented. In this study, rabbits were used for a preclinical assessment of nanosecond laser treatment.
Glyn Chidlow, John P. M. Wood, Weng Onn Chan, Robert J. Casson   +3 more
wiley   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo. [PDF]

Acta Physiol (Oxf)
Henderson GC, Buhman KK, Tomoo K.
europepmc   +1 more source

In vivo differentiation of scarring alopecia using line‐field confocal optical coherence tomography: a pilot study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives: Diagnosing cicatricial alopecia is challenging. Even with histology, a definitive diagnosis cannot always be made. Line‐field confocal optical coherence tomography (LC‐OCT), a non‐invasive imaging method with high resolution used in vivo, has proven helpful in diagnosing scarring alopecia.
Marie‐Christine Nutz, Julia Welzel, Daniela Hartmann, Lars E. French, Maximilian Deußing, Elke C. Sattler   +5 more
wiley   +1 more source