Results 131 to 140 of about 50,069 (263)

Distinct OA:PA Ratios Generate Discrete Hepatocellular Phenotypes in HepG2 Cells. [PDF]

Cells
Jeong H, Han Y, Park J, Noh H, Moon E, Huh Y.   +5 more
europepmc   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Metformin and atorvastatin ameliorate MASH via the AMPK/NF-κB pathway. [PDF]

Front Endocrinol (Lausanne)
Zhang B, Li N, Liu F, Wang G, Chen Q, Sun Y, Yang N, Zhang H, Han J.   +8 more
europepmc   +1 more source

The Effect of Familiarity Among Social Partners on the Jumping Behavior of Amazon Mollies

Ethology, EarlyView.
Pairs of familiar or nonfamiliar clonal Amazon mollies were tested in individual bowls, from which they could only escape from by jumping. Familiar pairs remained together significantly more than non‐familiar ones. Other behavioral aspects, such as timing and direction of jumps was not affected by familiarity.
Fritz A. Francisco, Ayla L. Kesim, David Bierbach   +2 more
wiley   +1 more source

Effect of Fenfluramine on convulsive seizures and rescue medication usage: A case series of adults within the Lennox-Gastaut syndrome spectrum. [PDF]

Epilepsy Behav Rep
Chilson L, Zaaimi B, Samarasekera S.
europepmc   +1 more source

High‐Intensity Interval Training Modulates NLRP3 Inflammasome‐Related Expression and Monocyte Subset Distribution in Adults With Obesity: A Randomised Trial

Immunology, EarlyView.
In sedentary adults with obesity, 8 weeks of high‐intensity interval training prevented the shift toward a pro‐inflammatory monocyte profile seen in nontrained controls—most robustly, a significantly lower proportion of intermediate monocytes at Week 8 (p = 0.014) while the control group also showed a within‐group rise in NLRP3 expression not observed ...
Daniela A. de Abreu, Ana Luíza P. A. Silveira, Stella de S. Vieira, Francisco A. H. Fonseca, Maria Cristina Izar, Jônatas B. do Amaral, Carolina N. França   +6 more
wiley   +1 more source

Free Fatty Acids and Sarcopenia Risk in Type 2 Diabetes: Insights From SHAP Analysis. [PDF]

Geriatr Gerontol Int
Yu Q, Ding M, Yu H, Di F, Jia G.
europepmc   +1 more source

Random‐key optimization for 2D irregular packing with reusable area evaluation

International Transactions in Operational Research, EarlyView.
Abstract The diverse constraints of industrial applications lead to variants of two‐dimensional (2D) irregular packing problems that require tailored solution methods. This paper addresses a real‐world industrial challenge by proposing a new problem definition, the maximum reusable contiguous area problem (MRCAP), and a novel metric, the maximum ...
Felipe S. C. Roberto, Victor U. Pugliese, Sanderson L. Gonzaga de Oliveira, Oseias Ferreira, Antonio A. Chaves, Fabio A. Faria   +5 more
wiley   +1 more source

Larval Arctic cod (Boreogadus saida) exhibit stronger developmental and physiological responses to temperature than to elevated pCO2

Journal of Fish Biology, EarlyView.
Abstract High‐latitude ecosystems are simultaneously warming and acidifying under ongoing climate change. Arctic cod (Boreogadus saida) are a key species in the Arctic Ocean and have demonstrated sensitivity to ocean warming and acidification as adults and embryos, but their larval sensitivity to the combined stressors is unknown. In a laboratory multi‐
Emily Slesinger, Louise A. Copeman, Benjamin J. Laurel, Mary Beth R. Hicks, Paul J. Iseri, Michelle A. Stowell, Thomas P. Hurst   +6 more
wiley   +1 more source