Results 41 to 50 of about 50,069 (263)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

E-Readiness of Government Staff toward E-Government Programs In Denpasar Municipality

JPAS (Journal of Public Administration Studies), 2016
This research is intended to analyse the readiness of non-IT staff toward e-government programs. It is located in Denpasar Municipality. The method employed in this study is quantitative in nature with questionnaires distribution.
Ida Ayu Cininta Padangratha
doaj   +1 more source

Heterogeneity of FFA responses or multiplexing? [PDF]

Trends in Cognitive Sciences, 2014
Recent work using cluster analysis of brain activity during movies revealed distinct clusters that respond to faces and different non-face categories in the fusiform face area (FFA). Because of the limited heterogeneity observed, these results could mean that the FFA contains one population of cells capable of representing multiple categories.
David A, Ross, Rankin W, McGugin, Isabel, Gauthier   +2 more
openaire   +2 more sources

Evaporation Kinetics Engineering Suppressed Bimolecular Recombination in All‐Polymer Solar Cells

Advanced Science, EarlyView.
In this study, phenanthrene (Ph), a volatile solid additive with a weak tendency toward self‐aggregation, is introduced as a donor‐selective morphology regulator in benchmark all‐PSC systems. The moderate evaporation kinetics of Ph enable cooperative crystallization of donors and acceptors, leading to an increased fractal dimension with reduced donor ...
Dinglong Feng, Le Mei, Chao Li, Yuang Fu, Heng Liu, Luhang Xu, Pok Fung Chan, Zhixiang Yang, Yiming Wang, Chun‐Jen Su, U‐Ser Jeng, Patrick Wai‐Keung Fong, Lijian Zuo, Gang Li, He Yan, Jiaying Wu, Xian‐Kai Chen, Xinhui Lu   +17 more
wiley   +1 more source

Bioinspired Porphyrin‐Based Catalysts From Temporospatial Confined Frameworks for Ultrafast Removal of Sulfaclozine

Advanced Science, EarlyView.
We report the rational design of artificial photocatalysts with asymmetrically coordinated dual‐metal centers and a tailored microenvironment, broadly applicable strategy is established for the synthesis of multivariate zirconium‐based metal–organic frameworks, offering a platform for precisely tuning active‐site configurations to optimize ...
Yuxin Lu, Yu‐Hang Li, Zhiyi Sun, Fanke Tong, Zelin Li, Sheng Wang, Shangkun Pei, Yi Li, Xiyan Xu, Chong‐Chen Wang, Bo Wang, Xiang Li   +11 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver

Drug Design, Development and Therapy, 2022
Yanan Feng,1,* Wenxiu Sun,2,* Fengcui Sun,1 Guoliang Yin,1 Pengpeng Liang,1 Suwen Chen,1 Xiangyi Liu,1 Tongfei Jiang,3 Fengxia Zhang4 1Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of China; 2Department of ...
Feng Y, Sun W, Sun F, Yin G, Liang P, Chen S, Liu X, Jiang T, Zhang F   +8 more
doaj  

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

The Jump Linkage Between International Dry Bulk Forward Freight Markets Based on SVCJ-TVP-VAR Model

Haiyang Kaifa yu guanli, 2023
In order to explore the risk linkage between different forward freight markets, this paper used the SVCJ-TVP-VAR model, selected the forward freight agreement (FFA) daily data of three ship types from 2014 to 2020, and analyzed the dynamic relationship ...
Hui ZHANG
doaj  

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source