Results 171 to 180 of about 11,138 (199)

Prostatic growth and development are regulated by FGF10

Development, 1999
Abstract We have examined the role of Fibroblast Growth Factor 10 (FGF10) during the growth and development of the rat ventral prostate (VP) and seminal vesicle (SV). FGF10 transcripts were abundant at the earliest stages of organ formation and during neonatal organ growth, but were low or absent in growth-quiescent adult organs. In both
A A, Thomson, G R, Cunha
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Fgf10 is essential for limb and lung formation

Nature Genetics, 1999
The interactions between fibroblast growth factors (FGF) and their receptors have important roles in mediating mesenchymal-epithelial cell interactions during embryogenesis. In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal expression pattern in the developing embryo.
K, Sekine, H, Ohuchi, M, Fujiwara, M, Yamasaki, T, Yoshizawa, T, Sato, N, Yagishita, D, Matsui, Y, Koga, N, Itoh, S, Kato   +10 more
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FGF10 and FGF21 as Regulators in Adipocyte Development and Metabolism

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2011
The FGF family comprises twenty-two evolutionarily related members with diverse functions in development, metabolism, and neuronal activities. FGF10 and FGF21 play unique roles in adipocyte development and metabolism, respectively. FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) with heparin/heparan sulfate in a paracrine ...
Hiroya, Ohta, Morichika, Konishi, Nobuyuki, Itoh   +2 more
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LADD syndrome is caused byFGF10mutations

Clinical Genetics, 2006
Lacrimo‐auriculo‐dento‐digital syndrome [LADD (MIM 149730)] is an autosomal‐dominant multiple congenital anomaly disorder characterized by aplasia, atresia or hypoplasia of the lacrimal and salivary systems, cup‐shaped ears, hearing loss, and dental and digital anomalies.
J M, Milunsky, G, Zhao, T A, Maher, R, Colby, D B, Everman   +4 more
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FGF10 regulates thalamocortical axon guidance in the developing thalamus

Neuroscience Letters, 2020
Thalamocortical axons (TCAs) transmit sensory information to the neocortex by responding to a variety of guidance cues in the environment. Similar to classical guidance cues (ephrins, slits, semaphorins and netrins), morphogens of FGFs can also help axons navigate to their targets.
Kuan Liu, Zhongsheng Lv, Hong Huang, Mingyue Li, Li Xiao, Xiang Li, Gang Li, Fang Liu   +7 more
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Multiple roles of FGF10 in the regulation of corneal endothelial wound healing

Experimental Eye Research, 2021
Corneal endothelial dysfunction usually induces corneal haze and oedema, which seriously affect visual function. The main therapeutic strategy for this condition is corneal transplantation, but the use of this strategy is limited by the shortage of healthy donor corneas. Compared with corneal transplantation, drug intervention is less invasive and more
Xin Wang, Qingjun Zhou, Can Zhao, Haoyun Duan, Wenjing Li, Chunxiao Dong, Yajie Gong, Zongyi Li, Weiyun Shi   +8 more
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Role of Fgf10 in cell proliferation in white adipose tissue

Molecular and Cellular Endocrinology, 2006
The development of white adipose tissue (WAT) involves adipogenesis and cell proliferation. Although the adipogenesis has been well studied, the cell proliferation has not. Therefore, we examined the mechanism of the proliferation by analyzing Fgf10(-/-) mouse embryonic WAT, in which adipogenesis and proliferation were severely impaired.
Morichika, Konishi, Toshiyuki, Asaki, Naomi, Koike, Hiroyuki, Miwa, Ayumi, Miyake, Nobuyuki, Itoh   +5 more
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Fgf10 regulates hepatopancreatic ductal system patterning and differentiation

Nature Genetics, 2007
During organogenesis, the foregut endoderm gives rise to the many different cell types that comprise the hepatopancreatic system, including hepatic, pancreatic and gallbladder cells, as well as the epithelial cells of the hepatopancreatic ductal system that connects these organs together and with the intestine.
Dong, P.D.S., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., Stainier, D.Y.R.   +7 more
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FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development

Development, 2000
ABSTRACT We investigated the mechanism of tissue induction and specification using the lacrimal gland as a model system. This structure begins its morphogenesis as a bud-like outgrowth of the conjunctival epithelium and ultimately forms a branched structure with secretory function.
H P, Makarenkova, M, Ito, V, Govindarajan, S C, Faber, L, Sun, G, McMahon, P A, Overbeek, R A, Lang   +7 more
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FGF10 Promotes Cardiac Repair Through a Dual Cellular Mechanism Increasing Cardiomyocyte Renewal and Inhibiting Fibrosis

Cardiovascular Research, 2022
Francesca Rochais, Nicolas Lenfant, Giovanna Mottola   +2 more
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