Results 211 to 220 of about 52,157 (235)

Maternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels

Journal of Affective Disorders, 2023
Recent research implicates fibroblast growth factor 2 (FGF2) in anxiety and depressive symptoms of childhood. This study is the first to examine an intergenerational pathway linking FGF2 levels in mothers to FGF2 levels in children, and to the children's anxiety and depressive symptoms.We assayed serum FGF2 in 259 mothers and their children, with a ...
Eli R, Lebowitz, Carla E, Marin, Meital, Orbach, Natalina, Salmaso, Flora M, Vaccarino, Wendy K, Silverman   +5 more
openaire   +2 more sources

Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2

Biochimica et Biophysica Acta (BBA) - General Subjects, 2018
Heparan sulfate proteoglycans are ubiquitously expressed on cell surfaces and in extracellular matrices, and are engaged in heparin-binding growth factor-related signal transduction. Thus, changes in the amounts, structures, and chain lengths of heparan sulfate have profound effects on aspects of cell growth controlled by heparin-binding growth factors
Satomi, Nadanaka, Hiroshi, Kitagawa
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The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Biochemical and Biophysical Research Communications, 2018
Cancers, including lung cancer, are a leading cause of death worldwide. To overcome this deadly disease, multiple modality inhibitors have been developed. These include cytotoxic agents, molecular targeted small molecules, such as tyrosine kinase inhibitors, and neutralizing antibodies.
Junko, Hamamoto, Hiroyuki, Yasuda, Yosuke, Nonaka, Masatoshi, Fujiwara, Yoshikazu, Nakamura, Kenzo, Soejima, Tomoko, Betsuyaku   +6 more
openaire   +2 more sources

Androgen receptor expression induces FGF2, FGF‐binding protein production, and FGF2 release in prostate carcinoma cells: Role of FGF2 in growth, survival, and androgen receptor down‐modulation

The Prostate, 2002
AbstractBACKGROUNDAlterations in fibroblast growth factors (FGFs) production and/or FGF receptors expression have been described to play key roles in prostate tumor progression, particularly in androgen‐independent tumors. However, the role of androgen receptor (AR) in altering FGF‐mediated growth and survival of prostatic neoplastic cells has not been
ROSINI P, BONACCORSI, LORELLA, BALDI, ELISABETTA, CHIASSERINI C, FORTI, GIANNI, DE CHIARA G, LUCIBELLO M, MONGIAT M, IOZZO RV, GARACI E, COZZOLINO, FEDERICO, TORCIA, MARIA   +11 more
openaire   +7 more sources

Inflammatory cells and chemokines sustain FGF2-induced angiogenesis

European Cytokine Network, 2009
Angiogenesis and inflammation are closely integrated processes in a number of physiological and pathological conditions, including wound healing, psoriasis, diabetic retinopathy, rheumatoid arthritis, arteriosclerosis, and cancer. Fibroblast growth factor-2 (FGF2) belongs to the family of the heparin-binding FGF growth factors.
PRESTA, Marco, ANDRÉS G, LEALI, Daria, DELL'ERA, Patrizia, RONCA, Roberto   +4 more
openaire   +2 more sources

Chromosomal localizations of mouse Fgf2 and Fgf5 genes

Mammalian Genome, 1992
The mouse Fgf2 and Fgf5 genes, two members of the FGF family whose human homologs are on the long arm of chromosome (chr) 4, were localized by using in situ chromosomal hybridization, to mouse Chrs 3 and 5, respectively.
M G, Mattei, M J, Pébusque, D, Birnbaum
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?????????????????????????????????? ?????????????????????? ???????????????????????????????? ???????????? ??????-??1 ?????? ???????????????? ?????????????????????????????? FGF2 ????????????????

2021
The aim of the investigation was to obtain the transgenic mammalian cell line CHO-K1 that expresses recombinant human FGF2 and secretes it into cultural medium and to compare the abilities of a monolyer cell culture and the cells encapsulated in alginate microcapsules to produce and to secrete this protein. Methods.
openaire   +1 more source

Mature Adipocytes and FGF2 Influence Angiogenic Processes

The FASEB Journal, 2020
The process of wound healing requires the transportation of substrates needed for the rebuilding of tissue through appropriate vessel formation; angiogenesis. Adipose tissue extract is often used to facilitate the wound healing process, which is attributed to its potent angiogenic ...
Makenzie Taylor Lowke, Xiomara Cortez, Michelle Renee Garcia   +2 more
openaire   +1 more source

FGF2 in asthmatic airway-smooth-muscle-cell hyperplasia

Trends in Molecular Medicine, 2008
Airway smooth muscle (ASM)-cell hyperplasia is a cardinal feature of the remodeled airways in asthma and contributes to airway hyper-responsiveness. Several upregulated mediators are potentially involved in this architectural change. Recently, many investigators have turned their interest toward fibroblast growth factor (FGF)2.
Ynuk, Bossé, Marek, Rola-Pleszczynski
openaire   +2 more sources

Gating of CNTF Signals by FGF2

Science's STKE, 2004
Ciliary neurotrophic factor (CNTF) promotes differentiation of cortical progenitor cells in rat brain into astrocytes. However, such progenitor cells become responsive to CNTF only later in development. Younger or "early" progenitors are not responsive to CNTF even though they express CNTF receptors and the STAT transcription factors normally activated
openaire   +1 more source