Results 221 to 230 of about 35,769 (259)

FGF2 is an endogenous regulator of alcohol reward and consumption

Addiction Biology, 2021
AbstractAlcohol use disorder (AUD) is a chronic, relapsing disorder, characterized by escalating alcohol drinking and loss of control, with very limited available treatments. We recently reported that the expression of fibroblast growth factor 2 (Fgf2) is increased in the striatum of rodents following long‐term excessive alcohol drinking and that the ...
Oren Even‐Chen, Leonie Herburg, Ekaterini Kefalakes, Nataly Urshansky, Claudia Grothe, Segev Barak   +5 more
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The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Biochemical and Biophysical Research Communications, 2018
Cancers, including lung cancer, are a leading cause of death worldwide. To overcome this deadly disease, multiple modality inhibitors have been developed. These include cytotoxic agents, molecular targeted small molecules, such as tyrosine kinase inhibitors, and neutralizing antibodies.
Junko, Hamamoto, Hiroyuki, Yasuda, Yosuke, Nonaka, Masatoshi, Fujiwara, Yoshikazu, Nakamura, Kenzo, Soejima, Tomoko, Betsuyaku   +6 more
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FGF2 Promotes Resistance To Quizartinib In Vitro, and FGF2 Increases In The Marrow Of Patients Prior To Resistance

Blood, 2013
Abstract Background Patients with acute myeloid leukemia and internal tandem duplication of fms-like tyrosine kinase receptor-3 (FLT3+ AML) make up about 25% of newly diagnosed AML and have a poor prognosis.
Elie Traer, Nathalie Javidi-Sharifi, Anupriya Agarwal, Jennifer B Dunlap, Isabel English, Jacqueline Martinez, Tibor J. Kovacsovics, Jeffrey W. Tyner, Melissa Wong, Brian J. Druker   +9 more
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FGF1 and FGF2 mutations in preeclampsia and related features

Placenta, 2016
Fibroblast growth factor (FGF) 1 and FGF2 were previously linked with preeclampsia (PE), possibly through altering decidual and placental FGFR2 expression. Since common variation in FGF1 and FGF2 might influence FGF1 and FGF2 activity, this study evaluated whether common FGF1 and FGF2 variants are linked with PE and associated features.The association ...
Ben Ali Gannoun Marwa, Nozha Raguema, Hedia Zitouni, Hachani Ben Ali Feten, Kacem Olfa, Raja Elfeleh, Wassim Almawi, Touhami Mahjoub   +7 more
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Chromosomal localizations of mouse Fgf2 and Fgf5 genes

Mammalian Genome, 1992
The mouse Fgf2 and Fgf5 genes, two members of the FGF family whose human homologs are on the long arm of chromosome (chr) 4, were localized by using in situ chromosomal hybridization, to mouse Chrs 3 and 5, respectively.
M G, Mattei, M J, Pébusque, D, Birnbaum
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Creating a neurogenic environment: The role of BDNF and FGF2

Molecular and Cellular Neuroscience, 2007
Regional environmental cues present in the adult brain determine the fate of adult neural progenitor cells. To determine whether the growth factors BDNF or FGF2 can create a neurogenic environment outside the SVZ, we used AAV(1/2)-mediated gene transfer to produce ectopic BDNF or FGF2 expression in the normal adult rat striatum and transplanted SVZ ...
Kevin, Chen, Rebecca A, Henry, Stephanie M, Hughes, Bronwen, Connor   +3 more
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?????????????????????????????????? ?????????????????????? ???????????????????????????????? ???????????? ??????-??1 ?????? ???????????????? ?????????????????????????????? FGF2 ????????????????

2021
The aim of the investigation was to obtain the transgenic mammalian cell line CHO-K1 that expresses recombinant human FGF2 and secretes it into cultural medium and to compare the abilities of a monolyer cell culture and the cells encapsulated in alginate microcapsules to produce and to secrete this protein. Methods.
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The human FGF2 level is influenced by genetic predisposition

International Journal of Cardiology, 2005
The fibroblast growth factor 2 (FGF2) is involved in various processes possibly leading to the development of complex diseases such as atherosclerosis. In recent studies, its cardioprotective properties, due to its ability to stimulate the proliferation of collateral vessels, could be shown.In this clinical study, the relation between clinical risk ...
Susanne, Schulz, Katrin, Köhler, Undraga, Schagdarsurengin, Petra, Greiser, Gerd, Birkenmeier, Ursula, Müller-Werdan, Karl, Werdan, Christiane, Gläser   +7 more
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Gating of CNTF Signals by FGF2

Science's STKE, 2004
Ciliary neurotrophic factor (CNTF) promotes differentiation of cortical progenitor cells in rat brain into astrocytes. However, such progenitor cells become responsive to CNTF only later in development. Younger or "early" progenitors are not responsive to CNTF even though they express CNTF receptors and the STAT transcription factors normally activated
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Inflammatory cells and chemokines sustain FGF2-induced angiogenesis

European Cytokine Network, 2009
Angiogenesis and inflammation are closely integrated processes in a number of physiological and pathological conditions, including wound healing, psoriasis, diabetic retinopathy, rheumatoid arthritis, arteriosclerosis, and cancer. Fibroblast growth factor-2 (FGF2) belongs to the family of the heparin-binding FGF growth factors.
PRESTA, Marco, ANDRÉS G, LEALI, Daria, DELL'ERA, Patrizia, RONCA, Roberto   +4 more
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