Results 211 to 220 of about 38,475 (260)

Silencing of miR‐497‐5p inhibits cell apoptosis and promotes autophagy in Parkinson's disease by upregulation of FGF2

Environmental Toxicology, 2021
Parkinson's disease (PD) is a progressive neurodegenerative disorder with increasing prevalence in elderly individuals globally. MicroRNAs (miRNAs) have been confirmed to participate in the pathogenesis of various neurodegenerative diseases, including PD.
Wenjie Zhu, Hui Zhang, Jun Gao, Yun Xu
semanticscholar   +1 more source

Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2

Biochimica et Biophysica Acta (BBA) - General Subjects, 2018
Heparan sulfate proteoglycans are ubiquitously expressed on cell surfaces and in extracellular matrices, and are engaged in heparin-binding growth factor-related signal transduction. Thus, changes in the amounts, structures, and chain lengths of heparan sulfate have profound effects on aspects of cell growth controlled by heparin-binding growth factors
Satomi, Nadanaka, Hiroshi, Kitagawa
openaire   +2 more sources

FGF2 is an endogenous regulator of alcohol reward and consumption

Addiction Biology, 2021
AbstractAlcohol use disorder (AUD) is a chronic, relapsing disorder, characterized by escalating alcohol drinking and loss of control, with very limited available treatments. We recently reported that the expression of fibroblast growth factor 2 (Fgf2) is increased in the striatum of rodents following long‐term excessive alcohol drinking and that the ...
Oren Even‐Chen, Leonie Herburg, Ekaterini Kefalakes, Nataly Urshansky, Claudia Grothe, Segev Barak   +5 more
openaire   +2 more sources

The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Biochemical and Biophysical Research Communications, 2018
Cancers, including lung cancer, are a leading cause of death worldwide. To overcome this deadly disease, multiple modality inhibitors have been developed. These include cytotoxic agents, molecular targeted small molecules, such as tyrosine kinase inhibitors, and neutralizing antibodies.
Junko, Hamamoto, Hiroyuki, Yasuda, Yosuke, Nonaka, Masatoshi, Fujiwara, Yoshikazu, Nakamura, Kenzo, Soejima, Tomoko, Betsuyaku   +6 more
openaire   +2 more sources

FGF2 and IL-1β – explorers of unconventional secretory pathways at a glance

Journal of Cell Science, 2020
Fibroblast growth factor 2 (FGF2) and interleukin 1β (IL-1β) were among the earliest examples of a subclass of proteins with extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER- and ...
M. T. Pallotta, W. Nickel
semanticscholar   +1 more source

FGF2 Promotes Resistance To Quizartinib In Vitro, and FGF2 Increases In The Marrow Of Patients Prior To Resistance

Blood, 2013
Abstract Background Patients with acute myeloid leukemia and internal tandem duplication of fms-like tyrosine kinase receptor-3 (FLT3+ AML) make up about 25% of newly diagnosed AML and have a poor prognosis.
Elie Traer, Nathalie Javidi-Sharifi, Anupriya Agarwal, Jennifer B Dunlap, Isabel English, Jacqueline Martinez, Tibor J. Kovacsovics, Jeffrey W. Tyner, Melissa Wong, Brian J. Druker   +9 more
openaire   +1 more source

LncRNA PCGEM1 promotes renal carcinoma progression by targeting miR-433-3p to regulate FGF2 expression

Cancer Biomarkers, 2020
Long non-coding RNAs (lncRNAs) are implicated in the development of carcinomas, containing renal carcinoma. The competing endogenous RNA (ceRNA) network is well-known in modulating the pathological and physiological processes of tumors.
Xianguo Cai, Xianjun Zhang, Licai Mo, Jialiang Zhu, Hongyuan Yu   +4 more
semanticscholar   +1 more source

?????????????????????????????????? ?????????????????????? ???????????????????????????????? ???????????? ??????-??1 ?????? ???????????????? ?????????????????????????????? FGF2 ????????????????

2021
The aim of the investigation was to obtain the transgenic mammalian cell line CHO-K1 that expresses recombinant human FGF2 and secretes it into cultural medium and to compare the abilities of a monolyer cell culture and the cells encapsulated in alginate microcapsules to produce and to secrete this protein. Methods.
openaire   +1 more source

Androgen receptor expression induces FGF2, FGF‐binding protein production, and FGF2 release in prostate carcinoma cells: Role of FGF2 in growth, survival, and androgen receptor down‐modulation

The Prostate, 2002
AbstractBACKGROUNDAlterations in fibroblast growth factors (FGFs) production and/or FGF receptors expression have been described to play key roles in prostate tumor progression, particularly in androgen‐independent tumors. However, the role of androgen receptor (AR) in altering FGF‐mediated growth and survival of prostatic neoplastic cells has not been
ROSINI P, BONACCORSI, LORELLA, BALDI, ELISABETTA, CHIASSERINI C, FORTI, GIANNI, DE CHIARA G, LUCIBELLO M, MONGIAT M, IOZZO RV, GARACI E, COZZOLINO, FEDERICO, TORCIA, MARIA   +11 more
openaire   +7 more sources

FGF1 and FGF2 mutations in preeclampsia and related features

Placenta, 2016
Fibroblast growth factor (FGF) 1 and FGF2 were previously linked with preeclampsia (PE), possibly through altering decidual and placental FGFR2 expression. Since common variation in FGF1 and FGF2 might influence FGF1 and FGF2 activity, this study evaluated whether common FGF1 and FGF2 variants are linked with PE and associated features.The association ...
Ben Ali Gannoun Marwa, Nozha Raguema, Hedia Zitouni, Hachani Ben Ali Feten, Kacem Olfa, Raja Elfeleh, Wassim Almawi, Touhami Mahjoub   +7 more
openaire   +2 more sources