Results 111 to 120 of about 19,752 (209)

Targeting Fibroblast Growth Factor 23 Signaling with Antibodies and Inhibitors, Is There a Rationale?

Frontiers in Endocrinology, 2018
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone mainly produced by bone. FGF23 reduces serum phosphate by suppressing intestinal phosphate absorption through reducing 1,25-dihydroxyvitamin D and proximal tubular phosphate reabsorption ...
Seiji Fukumoto
doaj   +1 more source

Fibroblast growth factor 23 and cardiovascular disease in patients with chronic kidney disease [PDF]

, 2018
Chronic kidney disease (CKD) has been known to be associated with an increased risk of cardiovascular (CV) mortality and morbidity in Japan. Although traditional risk factors contribute to the development of CV disease in CKD patients, they cannot fully ...
NITTA Kosaku
core   +2 more sources

FGF23 is correlated with iron status but not with inflammation and decreases after iron supplementation: a supplementation study. [PDF]

, 2012
BACKGROUND: Recent studies have described relationships between iron status and fibroblast growth factor-23 (FGF23) but the possible confounding effects of inflammation on iron status have not been considered. The aims of this study were a) to consider a

core   +1 more source

Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium.

PLoS ONE, 2014
Chronic kidney disease (CKD) is regarded as a state of Klotho deficiency and FGF23 excess. In patients with CKD a strong association has been found between increased serum FGF23 and mortality risk, possibly via enhanced atherosclerosis, vascular ...
Isabelle Six, Hirokazu Okazaki, Priscilla Gross, Joanna Cagnard, Cédric Boudot, Julien Maizel, Tilman B Drueke, Ziad A Massy   +7 more
doaj   +1 more source

Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices

Scientific Reports, 2017
Neutrophil trafficking in tissues critically regulates the body’s immune response. Neutrophil migration can either play a protective role in host defense or cause health problems.
Ke Yang, Hagit Peretz-Soroka, Jiandong Wu, Ling Zhu, Xueling Cui, Michael Zhang, Claudio Rigatto, Yong Liu, Francis Lin   +8 more
doaj   +1 more source

Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5-year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3 [PDF]

, 2017
Objectives Vitamin D deficiency, elevated fibroblast growth factor 23 (FGF23) and elevated parathyroid hormone (PTH) have each been associated with increased mortality in people with chronic kidney disease (CKD).
Fluck, Richard J., McIntyre, Christopher W., McIntyre, Natasha J., Shardlow, Adam, Taal, Maarten W.   +4 more
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Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism [PDF]

, 2017
Importance Secondary hyperparathyroidism contributes to extraskeletal complications in chronic kidney disease. Objective To evaluate the effect of the intravenous calcimimetic etelcalcetide on serum parathyroid hormone (PTH) concentrations in ...
Block, Geoffrey A., Bushinsky, David A., Chertow, Glenn M., Cunningham, John, Drueke, Tilman B., Ketteler, Markus, Kewalramani, Reshma, Martin, Kevin J., Mix, Christian, Moe, Sharon M., Patel, Uptal D., Silver, Justin, Spiegel, David M., Sterling, Lulu, Walsh, Liron   +14 more
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Analysis of salt transport indices, calcification markers, and FGF23 in patients with nephrolithiasis and crystalluria

Počki
Background. Nephrolithiasis (NL) is a common polyetiological urological disease that is frequently associated with reduced bone mineral density. One of the shared key factors contributing to both osteoporosis and NL is insufficient intake of calcium-rich
O. Nikitin, I. Kordubailo, O. Nishkumay, Mike K.S. Chan, D. Klokol   +4 more
doaj   +1 more source

FGF23 in hemodialysis patients is associated with left ventricular hypertrophy and reduced ejection fraction

Nefrología (English Edition), 2019
Background: Fibroblast growth factor 23 (FGF23) is known to cause left ventricular hypertrophy (LVH), but controversy exists concerning its effect in dialysis.
Ture Lange Nielsen, Louis Lind Plesner, Peder Emil Warming, Ole Hartvig Mortensen, Kasper Karmark Iversen, James Goya Heaf   +5 more
doaj   +1 more source

Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans [PDF]

, 2017
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean ...
A Loytynoja, AD Foote, AN Plotnikov, B Murrell, BA Armfield, C Charles, CL Myhrvold, D Kim, EM Munoz, H Barak, H Li, HS Yim, I Seim, IA Adzhubei, J Larson, J Schodel, J Yang, JE Tarver, JG Thewissen, JS Reidenberg, K Tamura, LN Cooper, M Goldfarb, M Harada, M Jarosz, M Keane, M Tekin, MD Robinson, MD Uhen, MR McGowen, MR McGowen, N Bhattacharyya, N Itoh, N Itoh, NM Gray, P Krejci, P Kumar, P Perelman, PH Fabre, PM Smallwood, R Tian, S Anders, S Mirceta, S Nummela, S Oulion, SL Pond, T Imamura, TA Demere, X Zhou, Y Choi, Y Nakatake, Y Wang, Z Chen, Z Yang, Z Yang, Z Yang, Z Yang   +56 more
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