Results 91 to 100 of about 17,111 (223)

Inflammation, iron and vitamin D metabolism in different cardiomyopathy aetiologies

Pteridines, 2020
Immune activation coincides with disturbances in iron and vitamin D metabolism in patients with cardiomyopathy. In this study, we investigated whether there are differences regarding immune activation, iron and vitamin D metabolism between the different ...
Lanser Lukas, Nemati Nada, Seifert Markus, Fuchs Dietmar, Weiss Günter, Pölzl Gerhard, Kurz Katharina   +6 more
doaj   +1 more source

Exploring the implications of blocking renin-angiotensin-aldosterone system and fibroblast growth factor 23 in early left ventricular hypertrophy without chronic kidney disease

Frontiers in Endocrinology, 2023
BackgroundWhether fibroblast growth factor 23 (FGF23) directly induces left ventricular hypertrophy (LVH) remains controversial. Recent studies showed an association between FGF23 and the renin-angiotensin-aldosterone system (RAAS). The aim of this study
Kentaro Watanabe, Hideki Fujii, Kohei Okamoto, Keiji Kono, Shunsuke Goto, Shinichi Nishi   +5 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis

International Journal of Molecular Sciences, 2020
The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis.
M. Mace, K. O̸lgaard, E. Lewin
semanticscholar   +1 more source

Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span

Biochemistry and Biophysics Reports, 2021
Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range.
Y. Takashi, S. Sawatsubashi, I. Endo, Yukiyo Ohnishi, M. Abe, M. Matsuhisa, Daiji Kawanami, Toshio Matsumoto, S. Fukumoto   +8 more
semanticscholar   +1 more source

Anti-FGF23 Neutralizing Antibodies Show the Physiological Role and Structural Features of FGF23 [PDF]

Journal of Bone and Mineral Research, 2008
Abstract Fibroblast growth factor (FGF)23 is proposed to play a physiological role in the regulation of phosphate and vitamin D metabolism; deranged circulatory levels of FGF23 cause several diseases with abnormal mineral metabolism.
Yuji, Yamazaki, Taro, Tamada, Noriyuki, Kasai, Itaru, Urakawa, Yukiko, Aono, Hisashi, Hasegawa, Toshiro, Fujita, Ryota, Kuroki, Takeyoshi, Yamashita, Seiji, Fukumoto, Takashi, Shimada   +10 more
openaire   +2 more sources

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

Hemodialysis International, EarlyView.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

FGF23-Mediated Activation of Local RAAS Promotes Cardiac Hypertrophy and Fibrosis

International Journal of Molecular Sciences, 2019
Patients with chronic kidney disease (CKD) are prone to developing cardiac hypertrophy and fibrosis, which is associated with increased fibroblast growth factor 23 (FGF23) serum levels.
Ineke Böckmann, Jonas Lischka, Beatrice Richter, Jennifer Deppe, A. Rahn, D. Fischer, J. Heineke, D. Haffner, M. Leifheit-Nestler   +8 more
semanticscholar   +1 more source

High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients

Scientific Reports, 2023
Vitamin D3 (25[OH]D3) insufficiency and fibroblast growth factor 23 (FGF23) elevation are usually attenuated after kidney transplantation (KT). However, elevated FGF23 may be associated with poor graft outcomes and vitamin D insufficiency after KT.
Jung-Hwa Ryu, Hee Jung Jeon, Ro Han, Hee-Yeon Jung, Myung-Gyu Kim, Kyu Ha Huh, Jae Berm Park, Kyung Pyo Kang, Seungyeup Han, Jaeseok Yang   +9 more
doaj   +1 more source