Results 81 to 90 of about 17,111 (223)

FGF23, a novel muscle biomarker detected in the early stages of ALS

Scientific Reports, 2021
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle weakness. Skeletal muscle is a prime source for biomarker discovery since it is one of the earliest sites to manifest disease pathology.
Ying Si, M. Kazamel, M. Benatar, J. Wuu, Yuri Kwon, Thaddaeus Kwan, Nan Jiang, Dominik Kentrup, C. Faul, Lyndsy Alesce, P. King   +10 more
semanticscholar   +1 more source

Relationship of Fibroblast Growth Factor 23 Serum Levels with Disease Characteristics in Systemic Lupus Erythematosus Patients

Biomolecules, 2023
Fibroblast growth factor 23 (FGF23), a hormone secreted by osteocytes and osteoblasts, is a major regulator of vitamin D and phosphate homeostasis. FGF23 has been associated with the disturbance of mineral homeostasis, and with kidney and cardiovascular ...
Yolanda Fernández-Cladera, Fuensanta Gómez-Bernal, María García-González, Juan C. Quevedo-Abeledo, Agustín F. González-Rivero, Antonia de Vera-González, Candelaria Martín-González, Ana L. Nunes-Andrade, Raquel López-Mejías, Miguel Á. González-Gay, Iván Ferraz-Amaro   +10 more
doaj   +1 more source

Association between serum α‐Klotho levels and severity of periodontitis in a representative U.S. population

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis, a chronic inflammatory disease, is linked to systemic conditions such as cardiovascular and kidney disease. Serum α‐Klotho, an anti‐aging protein with anti‐inflammatory properties, has been associated with systemic diseases, but its role in periodontitis is unclear.
Hamoun Sabri, Sahar Baniameri, Pranav Kataria, Hend Abulatifa, Parham Hazrati, Hom‐Lay Wang, Muhammad H. A. Saleh   +6 more
wiley   +1 more source

Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Phosphate (Pi) is essential for life; thus, serum Pi level is kept constant under tight regulation by fibroblast growth factor (FGF) 23.
Y. Takashi, H. Kosako, S. Sawatsubashi, Y. Kinoshita, N. Ito, M. Tsoumpra, M. Nangaku, M. Abe, M. Matsuhisa, S. Kato, Toshio Matsumoto, S. Fukumoto   +11 more
semanticscholar   +1 more source

PKC regulates the production of fibroblast growth factor 23 (FGF23).

PLoS ONE, 2019
Serine/threonine protein kinase C (PKC) is activated by diacylglycerol that is released from membrane lipids by phospholipase C in response to activation of G protein-coupled receptors or receptor tyrosine kinases.
Ludmilla Bär, Philipp Hase, Michael Föller   +2 more
doaj   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage

The FASEB Journal, 2021
Fibroblast growth factor 23 (FGF23) is a main regulator of mineral homeostasis. Low and high circulating FGF23 levels are associated with bone, renal, cardiovascular diseases, and increased mortality.
A. Daryadel, P. Ruiz, N. Gehring, D. Stojanović, M. Ugrica, Carla Bettoni, Sibylle Sabrautzki, E. Pastor-Arroyo, I. Frey-Wagner, B. Lorenz-Depiereux, T. Strom, M. H. de Angelis, G. Rogler, C. Wagner, I. Rubio-Aliaga   +14 more
semanticscholar   +1 more source

FGF23 in Acute and Chronic Illness [PDF]

Disease Markers, 2015
FGF23 is a bone-derived phosphaturic hormone that may become a useful biomarker for the identification of high-risk patients in chronic but also acute disease. It rises early in chronic kidney disease and is strongly and independently associated with excess morbidity and mortality.
Christian Schnedl, Astrid Fahrleitner-Pammer, Peter Pietschmann, Karin Amrein   +3 more
openaire   +2 more sources

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells

Pflügers Archiv: European Journal of Physiology, 2021
Myostatin is a signaling molecule produced by skeletal muscle cells (myokine) that inhibits muscle hypertrophy and has further paracrine and endocrine effects in other organs including bone.
F. Ewendt, M. Feger, M. Föller
semanticscholar   +1 more source