Results 1 to 10 of about 17,091 (230)

Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations

Frontiers in Aging, 2022
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia ...
Merve Kurt, Gerald J Prud'homme, Qinghua Wang   +2 more
exaly   +3 more sources

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1-Dependent Suppression of ROMK. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Kawarazaki W, Ayuzawa N, Nishimoto M, Hirohama D, Ueda K, Marumo T, Fujita T.   +6 more
europepmc   +2 more sources

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor-αKlotho Complex Increases Sinoatrial Electrical Activity. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Bertoli G, Benzoni P, Canzolino S, Molla D, Milanesi R, Piantoni C, Kuro-O M, Delgado C, Ruiz-Hurtado G, Baruscotti M, Bucchi A.   +10 more
europepmc   +2 more sources

Klotho-Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A. [PDF]

Adv Sci (Weinh)
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Zhang X, Lin S, Wu T, Zhang Z, Zhou H, Hong X, Liu Y.   +6 more
europepmc   +2 more sources

Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging

Cells
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia and other anomalies.
Gerald J Prud'homme, Qinghua Wang
exaly   +3 more sources

Association between soluble Klotho levels and calcification propensity T50 in patients with hemodialysis: a cross-sectional study [PDF]

Scientific Reports
Soluble Klotho is an anti-aging hormone implicated in vascular calcification. The calcification propensity score (T50) is a method used to evaluate the calcification propensity.
Akio Nakashima, Kazuhiko Kato, Arisa Kobayashi, Rena Kawai, Yuriko Shibata, Saya Tanimoto, Chiharu Aizawa, Keita Kimura, Ichiro Ohkido, Takashi Yokoo   +9 more
doaj   +2 more sources

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases [PDF]

CNS Neurosci Ther
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Tian Q, Tong Y, Yu F, Hu X.
europepmc   +2 more sources

Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken [PDF]

Poultry Science
This study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups.
Yaser Hassania, Shahin Hassanpour, Morteza Zendehdel, Bita Vazir   +3 more
doaj   +2 more sources

Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

Frontiers in Psychiatry, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao, Zuoli Sun, Guangwei Ma, Yuhong Li, Min Liu, Guofu Zhang, Hong Xu, Yane Gao, Jixuan Zhou, Qi Deng, Rena Li, Rena Li   +11 more
doaj   +1 more source

The Role and Molecules Mechanism of Klotho in Renal Injury in Salt-sensitive Hypertension [PDF]

Zhongguo quanke yixue, 2023
Background Klotho is closely related to the occurrence and development of kidney disease. Salt-sensitive hypertension (SSH) is often accompanied by kidney disease.
ZHAO Wei, TANG Rongjie, YANG Shanshan, YANG Fang, SUN Feng, LIAN Qiufang
doaj   +1 more source