Results 1 to 10 of about 11,920 (192)

Klotho, Aging, and the Failing Kidney [PDF]

Frontiers in Endocrinology, 2020
Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family.
Emilie Combet, Peter Stenvinkel, Paul G Shiels   +2 more
exaly   +6 more sources

Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations

Frontiers in Aging, 2022
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia ...
Gerald J Prud'homme, Merve Kurt
exaly   +3 more sources

Reduced Circulating α‐Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background α‐Klotho is a multifunctional protein implicated in vascular aging. Declining Klotho levels are associated with arterial stiffness, endothelial dysfunction, and vascular calcification.
Elias Hellou, Parvin Kalhor, Ali Babaie, Nadia Akhiyat, Negin Mahmoudi Hamidabad, Valentina Nardi, Matteo Manzato, Kai Nogami, Elizabeth Copley, Lilach O Lerman, Amir Lerman   +10 more
doaj   +2 more sources

Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

Frontiers in Psychiatry, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao, Zuoli Sun, Guangwei Ma, Yuhong Li, Min Liu, Guofu Zhang, Hong Xu, Yane Gao, Jixuan Zhou, Qi Deng, Rena Li, Rena Li   +11 more
doaj   +1 more source

Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. [PDF]

PLoS ONE, 2013
Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. Although Klotho was recently reported to exhibit tumor suppressive properties during various malignant ...
Lin Chen, Haiou Liu, Jing Liu, Yu Zhu, Le Xu, Hongyong He, Heng Zhang, Shanshan Wang, Qian Wu, Weisi Liu, Yidong Liu, Deng Pan, Shifang Ren, Jiejie Xu, Jianxin Gu   +14 more
doaj   +1 more source

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

Molecular Metabolism, 2021
Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry, Peixin Li, Daniel Shookster, Zhiying Jiang, Hongli Li, Brenton Thomas Laing, Wyatt Bunner, Theodore Langton, Qingchun Tong, Hu Huang   +9 more
doaj   +1 more source

Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes [PDF]

Archives of Biological Sciences, 2022
All-trans retinoic acid (RA) is an effective anti-aging chemical substance widely used in skin-care products. RA compromises epidermal differentiation and induces keratinocyte proliferation, causing hyaluronic acid production through mechanisms that are ...
Choi Hyangtae, Lee Yonghee, Park Won-seok, Kim Beom Joon, Lee Chang Seok   +4 more
doaj   +1 more source

Analysis of Immune Responses in Acinetobacter baumannii-Infected Klotho Knockout Mice: A Mouse Model of Acinetobacter baumannii Infection in Aged Hosts

Frontiers in Immunology, 2020
Acinetobacter baumannii is an important opportunistic pathogen that primarily afflicts elderly people. To clarify the pathogenicity of A. baumannii in the elderly, we investigated immune responses to A.
Yoshinori Sato, Shigeru Tansho-Nagakawa, Tsuneyuki Ubagai, Yasuo Ono   +3 more
doaj   +1 more source

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy.

PLoS ONE, 2021
The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood.
Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee   +8 more
doaj   +1 more source

The Role and Molecules Mechanism of Klotho in Renal Injury in Salt-sensitive Hypertension [PDF]

Zhongguo quanke yixue, 2023
Background Klotho is closely related to the occurrence and development of kidney disease. Salt-sensitive hypertension (SSH) is often accompanied by kidney disease.
ZHAO Wei, TANG Rongjie, YANG Shanshan, YANG Fang, SUN Feng, LIAN Qiufang
doaj   +1 more source