Results 31 to 40 of about 17,091 (230)
Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes [PDF]
Archives of Biological Sciences, 2022 All-trans retinoic acid (RA) is an effective anti-aging chemical substance widely used in skin-care products. RA compromises epidermal differentiation and induces keratinocyte proliferation, causing hyaluronic acid production through mechanisms that are ...
Choi Hyangtae +4 more
doaj +1 more source
Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia
, 2022 Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years.
YALÇIN, MEHMET MUHİTTİN +13 more
core +1 more source
Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney.
Kidney & Blood Pressure Research, 2023 Introduction: While recent investigations show that klotho exerts reno-protective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage.
Tsuneo Takenaka +9 more
doaj +1 more source
Klotho and Renal Fibrosis [PDF]
Nephro-Urology Monthly, 2013 Klotho is a newly discovered protein with pleotropic effects and have affected different fields of renal medicine from translational research to clinical nephrology. Here we want to summarize some new scopes in the field of renal fibrosis and Klotho with this hope that in future it could be implemented as a new therapeutic strategy to combat the renal ...
Zununi Vahed, Sepide +2 more
openaire +2 more sources
Growth hormone and Klotho [PDF]
Journal of Endocrinology, 2013 Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma.
Schmid, Christoph +4 more
openaire +3 more sources
Interaction of Klotho and sirtuins
Experimental Gerontology, 2023 In this article, we review the articles that have reported the interaction between Klotho and sirtuins.Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms.
Farzaneh Rostamzadeh +2 more
openaire +3 more sources
EBioMedicine, 2019 Background: The klotho (KL) gene is an anti-aging gene that has recently been shown to also function as a general tumor suppressor. However, there is currently only limited information regarding the potential molecular signals for regulation of Klotho ...
Bo Chen +10 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009 The klotho gene encodes a single-pass transmembrane protein that forms a complex with multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor for FGF23, a bone-derived hormone that induces negative phosphate balance.
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The vascular secret of Klotho [PDF]
Kidney International, 2015 Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise ...
Ewa, Lewin, Klaus, Olgaard
openaire +2 more sources
Kidney International, 2011 Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In addition to multiple endocrine organs, Klotho is expressed in kidney distal convoluted tubules and parathyroid cells, mediating the role of FGF-23 in bone-kidney-parathyroid control ...
openaire +3 more sources