Results 31 to 40 of about 11,920 (192)
PLoS ONE, 2020 Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers.
Ci-Di Chen +7 more
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Circulation, 2012 Finding the mechanism that will make us live a long and healthy life is the goal of medical research. How appropriate that Klotho, the Greek goddess of life is involved in vascular disease. Klotho is one of the Greek Moirai, the goddesses of fate who controlled the ultimate destiny of man: death.
openaire +2 more sources
Effects of klotho protein or klotho knockdown in porcine oocytes at different stages
Zygote, 2023 SummaryKlotho is a protein that plays different functions in female fertility. We have previously reported that klotho protein supplementation during in vitro maturation improves porcine embryo development, while klotho knockout for somatic cell cloning completely blocks full-term pregnancy in vivo.
Eun Pyo Kim +5 more
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Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
Journal of Experimental & Clinical Cancer Research, 2010 Background Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes.
Zhao Weihong +3 more
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Indonesian Biomedical Journal, 2022 BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis.
Hendri Susilo +8 more
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Nefrología (English Edition), 2019 Background: Klotho is found in two forms: a transmembrane form and a soluble form (s-Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach the proximal convoluted tubule by a transcytosis process.
Flaviu Bob +14 more
doaj +3 more sources
Frontiers in Cellular Neuroscience, 2019 The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li +5 more
doaj +1 more source
Serum α-Klotho associated with oral health among a nationally representative sample of US adults
Frontiers in Endocrinology, 2022 BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen +5 more
doaj +1 more source
Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people
European Journal of Medical Research, 2022 Background Soluble Klotho (S-Klotho) is an anti-aging protein mainly secreted by the kidneys. Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases.
Haitao Xie +9 more
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source