Results 41 to 50 of about 17,091 (230)

Soluble α-Klotho Serum Levels in Chronic Kidney Disease

International Journal of Endocrinology, 2015
Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport.
Silverio Rotondi, Marzia Pasquali, Lida Tartaglione, Maria Luisa Muci, Giusy Mandanici, Cristiana Leonangeli, Silvia Sales, Alessio Farcomeni, Sandro Mazzaferro   +8 more
doaj   +1 more source

The Organ Handling of Soluble Klotho in Humans

Kidney & Blood Pressure Research, 2019
Background: Chronic kidney disease (CKD) reduces both Klotho expression and its shedding into circulation, an effect that accelerates progression and cardiovascular complications.
Daniela Picciotto, Abitha Murugavel, Francesca Ansaldo, Gian Marco Rosa, Antonella Sofia, Samantha Milanesi, Francesca Viazzi, Michela Saio, Manrico Balbi, Giacomo Garibotto, Daniela Verzola   +10 more
doaj   +1 more source

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Cell Death and Disease, 2023
Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim   +3 more
doaj   +1 more source

microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress.

PLoS ONE, 2019
KLOTHO deficiency is associated with the progression of kidney dysfunction, whereas its overexpression exerts renoprotective effects. Oxidative stress suppresses KLOTHO expression in renal epithelial cells but upregulates microRNA-200c (miR-200c) in ...
Kenichi Morii, Satoshi Yamasaki, Shigehiro Doi, Taisuke Irifuku, Kensuke Sasaki, Toshiki Doi, Ayumu Nakashima, Koji Arihiro, Takao Masaki   +8 more
doaj   +1 more source

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho.

PLoS ONE, 2020
Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers.
Ci-Di Chen, Yuexuan Li, Arthur K Chen, Melissa A Rudy, Jason S Nasse, Ella Zeldich, Taryn J Polanco, Carmela R Abraham   +7 more
doaj   +1 more source

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

Journal of Experimental & Clinical Cancer Research, 2010
Background Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes.
Zhao Weihong, Wang Xueli, Chen Bo, Wu Jianqing   +3 more
doaj   +1 more source

The role of Memo in premature aging and FGFR signaling [PDF]

, 2012
Memo was recently identified in a screen for proteins required for ErbB receptor induced cell migration. Encoded by a single-copy gene present in all branches of life, it is ubiquitously expressed during all stages of embryogenesis and in adult tissues ...
Hänzi, Barbara
core   +1 more source

Antiaging Factor Klotho Retards the Progress of Intervertebral Disc Degeneration through the Toll-Like Receptor 4-NF-κB Pathway

International Journal of Cell Biology, 2020
Antiaging protein Klotho exhibits impressive properties of anti-inflammation, however is declined early after intervertebral disc injury, making Klotho restoration an attractive strategy of treating intervertebral disc inflammatory disorders.
Fangfang Bi, Wenbo Liu, Zongtao Wu, Chen Ji, Cuicui Chang   +4 more
doaj   +1 more source

Klotho [PDF]

Circulation, 2012
Finding the mechanism that will make us live a long and healthy life is the goal of medical research. How appropriate that Klotho, the Greek goddess of life is involved in vascular disease. Klotho is one of the Greek Moirai, the goddesses of fate who controlled the ultimate destiny of man: death.
openaire   +2 more sources

Rapid decline of kidney function in diabetic kidney disease is associated with high soluble Klotho levels

Nefrología (English Edition), 2019
Background: Klotho is found in two forms: a transmembrane form and a soluble form (s-Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach the proximal convoluted tubule by a transcytosis process.
Flaviu Bob, Adalbert Schiller, Romulus Timar, Daniel Lighezan, Oana Schiller, Bogdan Timar, Cristiana Georgeta Bujor, Mircea Munteanu, Florica Gadalean, Adelina Mihaescu, Iulia Grosu, Andreea Hategan, Lazar Chisavu, Agneta-Maria Pusztai, Adrian Covic   +14 more
doaj   +3 more sources