Results 41 to 50 of about 11,920 (192)
Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression [PDF]
Kidney International, 2013 Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a fibroblast growth factor-23 (FGF23)-dependent and an FGF23-independent manner.
Drüeke, Tilman B., Massy, Ziad A.
openaire +2 more sources
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Upregulation of the Creatine Transporter Slc6A8 by Klotho
Kidney & Blood Pressure Research, 2014 Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and
Ahmad Almilaji +8 more
doaj +1 more source
Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice
Biology, 2023 The Klotho null mutation is known to lead to accelerated aging in many organs, but its effects on tear secretion and lacrimal gland (LG) senescence have not been addressed.
Chun-Yen Wu +7 more
doaj +1 more source
Equine models in translational medicine: A comparative approach to human health
Animal Models and Experimental Medicine, EarlyView.This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh +1 more
wiley +1 more source
Neuroprotective Role of Klotho on Dementia
Cureus, 2023 Klotho, a gene found on chromosome 13q12, is involved in a variety of processes and signaling pathways in the human body related to vitamin D metabolism; cardiovascular, renal, musculoskeletal, and skin diseases; and cancer biology. However, more importantly, it has been linked to beneficial effects related to anti-aging.
Ananya, Fariha Noor +7 more
openaire +2 more sources
Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo
Genetics and Molecular BiologyKlotho is originally discovered as an anti-aging gene and knock-out of klotho accelerates aging in mice. Subsequent studies support the anti-carcinogenesis role of klotho in a variety of human malignancies.
Ying Li, Hai-jun Xiao, Feng Xue
doaj +1 more source
BMC Nephrology, 2012 Background Klotho is a single-pass transmembrane protein, which appears to be implicated in aging. The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function in patients with various degrees ...
Akimoto Tetsu +15 more
doaj +1 more source
Failure to maintain full-term pregnancies in pig carrying klotho monoallelic knockout fetuses
BMC Biotechnology, 2021 Background Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals such as pigs.
Sanghoon Lee +9 more
doaj +1 more source
Tobacco Induced Diseases, 2022 Introduction Serum cotinine is a sensitive and specific marker of tobacco smoke exposure. α-Klotho is an anti-ageing molecule, which plays an important role in several diseases.
Yu Yao +4 more
doaj +1 more source