Results 41 to 50 of about 12,216 (191)

Podocyte mPGES-2 Determines Renal Aging and Contributes to Senile Osteoporosis. [PDF]

Aging Cell
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Zhong D, Hao C, Li M, Liu J, Xu Z, Zhou J, Zhao L, Ni S, Hu Z, Sun Y, Zou Y, Sun D, Guo H, Jia Z, Guo D, Cao JL, Sun Y.   +16 more
europepmc   +2 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression [PDF]

Kidney International, 2013
Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a fibroblast growth factor-23 (FGF23)-dependent and an FGF23-independent manner.
Drüeke, Tilman B., Massy, Ziad A.
openaire   +2 more sources

Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo

Genetics and Molecular Biology
Klotho is originally discovered as an anti-aging gene and knock-out of klotho accelerates aging in mice. Subsequent studies support the anti-carcinogenesis role of klotho in a variety of human malignancies.
Ying Li, Hai-jun Xiao, Feng Xue
doaj   +1 more source

Upregulation of the Creatine Transporter Slc6A8 by Klotho

Kidney & Blood Pressure Research, 2014
Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and
Ahmad Almilaji, Mentor Sopjani, Bernat Elvira, José Borras, Miribane Dërmaku-Sopjani, Carlos Munoz, Jamshed Warsi, Undine E. Lang, Florian Lang   +8 more
doaj   +1 more source

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Frontiers in Endocrinology, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen, Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yin   +5 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

BMC Nephrology, 2012
Background Klotho is a single-pass transmembrane protein, which appears to be implicated in aging. The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function in patients with various degrees ...
Akimoto Tetsu, Yoshizawa Hiromichi, Watanabe Yuko, Numata Akihiko, Yamazaki Tomoyuki, Takeshima Eri, Iwazu Kana, Komada Takanori, Otani Naoko, Morishita Yoshiyuki, Ito Chiharu, Shiizaki Kazuhiro, Ando Yasuhiro, Muto Shigeaki, Kuro-o Makoto, Kusano Eiji   +15 more
doaj   +1 more source

Failure to maintain full-term pregnancies in pig carrying klotho monoallelic knockout fetuses

BMC Biotechnology, 2021
Background Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals such as pigs.
Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park, Byeong Chun Lee   +9 more
doaj   +1 more source

Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice

Biology, 2023
The Klotho null mutation is known to lead to accelerated aging in many organs, but its effects on tear secretion and lacrimal gland (LG) senescence have not been addressed.
Chun-Yen Wu, Da-Fong Song, Tsung-Han Lu, Zhi-Jia Chen, Su-Min Tsai, Ya-Jing Liu, Han-Hsin Chang, David Pei-Cheng Lin   +7 more
doaj   +1 more source