Results 61 to 70 of about 17,091 (230)

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, EarlyView.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people

European Journal of Medical Research, 2022
Background Soluble Klotho (S-Klotho) is an anti-aging protein mainly secreted by the kidneys. Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases.
Haitao Xie, Ning Li, Guowei Zhou, Qian Liu, Haiyan Wang, Jie Han, Le Shen, Peng Yu, Jiandong Chen, Xiaohu Chen   +9 more
doaj   +1 more source

Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice

Biology, 2023
The Klotho null mutation is known to lead to accelerated aging in many organs, but its effects on tear secretion and lacrimal gland (LG) senescence have not been addressed.
Chun-Yen Wu, Da-Fong Song, Tsung-Han Lu, Zhi-Jia Chen, Su-Min Tsai, Ya-Jing Liu, Han-Hsin Chang, David Pei-Cheng Lin   +7 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging [PDF]

, 2016
Cognitive decline is a major biomedical challenge as the global population ages. Elevated levels of the longevity factor klotho suppress aging, enhance cognition, and promote synaptic plasticity and neural resilience against aging and Alzheimer’s disease
Bonham, Luke W, Dubal, Dena B, Jesse A. Brown, Brown, Jesse A, Wang, Dan, Jennifer S. Yokoyama, Kramer, Joel H, Gabe Marx, Yokoyama, Jennifer S, Luke W. Bonham, Giovanni Coppola, Bruce L. Miller, Dena B. Dubal, Coppola, Giovanni, William W. Seeley, Howard J. Rosen, Marx, Gabe, Rosen, Howard J, Seeley, William W, Joel H. Kramer, Dan Wang, Miller, Bruce L   +21 more
core   +2 more sources

Association between serum cotinine and α-Klotho levels among adults: Findings from the National Health and Nutrition Examination Survey 2007–2016

Tobacco Induced Diseases, 2022
Introduction Serum cotinine is a sensitive and specific marker of tobacco smoke exposure. α-Klotho is an anti-ageing molecule, which plays an important role in several diseases.
Yu Yao, Ying Long, Fa-Wang Du, Yong Zhao, Xiao-Bin Luo   +4 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

Journal of Hematology & Oncology, 2017
Background Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways.
Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv, Xin Wang   +9 more
doaj   +1 more source

Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions

BMEMat, EarlyView.
Substrate stiffness with different dimensions (2D and 3D) exerts a regulatory role in cellular behaviors, thereby governing cell fate decisions. Biomaterials with tunable stiffness exhibit substantial functional potential for the repair and regeneration of the motor system.
Zhiyuan Lu, Renwang Sheng, Ludvig J. Backman, Chuanquan Liu, Danning Zheng, Wei Zhang, Jialin Chen   +6 more
wiley   +1 more source

a-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

, 2023
a-Klotho, a multifunctional protein, has been demonstrated to protect tissues from\r\ninjury via anti-oxidation and anti-inflammatory effects. The expression of a-klotho is\r\nregulated by several physiological and pathological factors, including acute ...
Rao, Zhijian, Feng, Yu, Huang, Hu, Zheng, Lifang, Shi, Rengfei, NC DOCKS at East Carolina University   +5 more
core