Results 61 to 70 of about 12,216 (191)

Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging

Cells
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia and other anomalies.
Gérald J. Prud’homme, Qinghua Wang
doaj   +1 more source

Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants

Frontiers in Public Health, 2023
PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of ...
Min Li, Min Li, Yuanlin Ma, Wenli Cheng, Luyun Zhang, Cheng Zhou, Wenji Zhang, Wenjuan Zhang   +7 more
doaj   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

Urinary Incontinence and Risk of All‐Cause Mortality: A Systematic Review and Meta‐Analysis of Observational Studies

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Urinary incontinence (UI) is a prevalent condition among adults and imposes a substantial societal burden, yet its association with all‐cause mortality remains uncertain. This study systematically reviewed and quantified the association between UI and mortality risk.
Yanyan Zhou, Liwei Wang, Weijia Sun, Zhong Wang, Kuiqing Shao, Feng Xu, Zhan Gao   +6 more
wiley   +1 more source

Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho

Renal Failure, 2023
Background Peritoneal fibrosis caused by long-term peritoneal dialysis (PD) is the main reason why patients withdraw from PD treatment. Lipid accumulation in the peritoneum was shown to participate in fibrosis, and klotho is a molecule involved in lipid ...
Qinglian Wang, Jingshu Sun, Rong Wang, Jing Sun   +3 more
doaj   +1 more source

Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity

Obesity, EarlyView.
Protein restriction, while meeting minimum requirements, induced weight loss and increased FGF21 in men with obesity under isocaloric conditions, without caloric restriction. ABSTRACT Objective Dietary protein reduction increases plasma fibroblast growth factor 21 (FGF21) and energy requirements in lean men under eucaloric conditions.
Aslak E. Lyster, Amalie S. Frederiksen, Jacob K. Jensen, Annemarie Lundsgaard, Nicoline R. Andersen, Kasper S. Jørgensen, Daniela Weber, Lukas Nachtigall, Erik A. Richter, Andreas M. Fritzen, Bente Kiens   +10 more
wiley   +1 more source

Klotho and the Aging Process

The Korean Journal of Internal Medicine, 2011
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life.
openaire   +2 more sources

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Shedding of klotho by ADAMs in the kidney [PDF]

American Journal of Physiology-Renal Physiology, 2015
The anti-aging gene klotho plays an important role in Ca2+and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM)10 and ADAM17.
Loon, E.P.M. van, Pulskens, W.P.C., Hagen, E.A.E. van der, Lavrijsen, M., Vervloet, M.G., Goor, H. van, Bindels, R.J.M., Hoenderop, J.G.J.   +7 more
openaire   +7 more sources

Effect of Two Therapeutic Renal Diets on Hormonal and Regulatory Pathways Affecting Calcium Homeostasis in Cats With Early‐Stage Chronic Kidney Disease

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall, Elizabeth M. Morris, Dale A. Fritsch, John J. Brejda, Kim M. Wilson   +4 more
wiley   +1 more source