Results 71 to 80 of about 17,091 (230)
Scientific ReportsKlotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief urinary K+ secretion channel (ROMK) and stimulates ...
Hyun Jun Jung +9 more
doaj +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
, 2021 It is well established that animal models of α-Klotho deficiency are characterized by an aging phenotype. With the advent of research in the biological mechanisms of aging it has become clear that the kidney-derived α-Klotho protein has a key role in ...
Hillebrands, Jan-Luuk; id_orcid +4 more
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Shedding of klotho by ADAMs in the kidney [PDF]
American Journal of Physiology-Renal Physiology, 2015 The anti-aging gene klotho plays an important role in Ca2+and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM)10 and ADAM17.
Loon, E.P.M. van +7 more
openaire +7 more sources
Frontiers in Public Health, 2023 PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of ...
Min Li +7 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Funktionelle Studien zur Signaltransduktion von Klotho [PDF]
, 2011 Klotho ist ein Typ I Transmembranprotein, das als solches oder nach Abspaltung seiner extrazellulären Domäne als sezernierter löslicher Faktor eine Rolle in einer Vielzahl an Signaltransduktionwegen spielt. So kann Klotho z.B.
Krop, Friederike
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Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli +5 more
wiley +1 more source
개의 유선종양에서 예후 인자로서의 klotho 효용성 연구 [PDF]
, 2022 학위논문(석사) -- 서울대학교대학원 : 수의과대학 수의학과, 2022. 8. 김완희.Klotho가 항노화 유전자로 발견된 이후, klotho는 종양과의 연관성에 대해 연구되어 왔다. 이전의 몇몇 연구들은 사람의 다양한 종양에서 klotho의 발현 감소를 보고했고, 관련한 메커니즘의 많은 부분이 밝혀진 바 있다. 그럼에도 불구하고 개 유선종양에서 klotho의 중요성은 아직 알려져 있지 않다.
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Klotho and activin A in kidney injury: plasma Klotho is maintained in unilateral obstruction despite no upregulation of Klotho biosynthesis in the contralateral kidney [PDF]
American Journal of Physiology-Renal Physiology, 2018 In a new paradigm of etiology related to chronic kidney disease-mineral and bone disorder (CKD-MBD), kidney injury may cause induction of factors in the injured kidney that are released into the circulation and thereby initiate and maintain renal fibrosis and CKD-MBD.
Nordholm, Anders +6 more
openaire +3 more sources