Results 1 to 10 of about 7,246 (143)

Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

Frontiers in Psychiatry, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao, Zuoli Sun, Guangwei Ma, Yuhong Li, Min Liu, Guofu Zhang, Hong Xu, Yane Gao, Jixuan Zhou, Qi Deng, Rena Li, Rena Li   +11 more
doaj   +1 more source

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

Molecular Metabolism, 2021
Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry, Peixin Li, Daniel Shookster, Zhiying Jiang, Hongli Li, Brenton Thomas Laing, Wyatt Bunner, Theodore Langton, Qingchun Tong, Hu Huang   +9 more
doaj   +1 more source

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Cell Death and Disease, 2023
Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim   +3 more
doaj   +1 more source

Association between serum cotinine and α-Klotho levels among adults: Findings from the National Health and Nutrition Examination Survey 2007–2016

Tobacco Induced Diseases, 2022
Introduction Serum cotinine is a sensitive and specific marker of tobacco smoke exposure. α-Klotho is an anti-ageing molecule, which plays an important role in several diseases.
Yu Yao, Ying Long, Fa-Wang Du, Yong Zhao, Xiao-Bin Luo   +4 more
doaj   +1 more source

Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants

Frontiers in Public Health, 2023
PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of ...
Min Li, Min Li, Yuanlin Ma, Wenli Cheng, Luyun Zhang, Cheng Zhou, Wenji Zhang, Wenjuan Zhang   +7 more
doaj   +1 more source

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Frontiers in Endocrinology, 2022
BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen, Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yin   +5 more
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Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study

Scientific Reports, 2023
Alpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers.
Rui Du, Xiaoyan Tang, Meihua Jiang, Shengli Qian, Li Yang, Xiaoling Tong, Wei Huang   +6 more
doaj   +1 more source

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Frontiers in Cellular Neuroscience, 2019
The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li, Dongqing Jing, Ziyang Liu, Ying Chen, Fang Huang, Thomas Behnisch   +5 more
doaj   +1 more source

Soluble α-klotho as a novel biomarker in the early stage of nephropathy in patients with type 2 diabetes. [PDF]

PLoS ONE, 2014
OBJECTIVE: Although α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated.
Eun Young Lee, Sang Soo Kim, Ji-Sung Lee, In Joo Kim, Sang Heon Song, Seung-Kuy Cha, Kyu-Sang Park, Jeong Suk Kang, Choon Hee Chung   +8 more
doaj   +1 more source

α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells. [PDF]

PLoS ONE, 2017
Endothelial cells (ECs) express fibroblast growth factor (FGF) receptors and are metabolically active after treatment with FGF-23. It is not known if this effect is α-Klotho independent or mediated by humoral or endogenous endothelial α-Klotho.
Chih-Ping Chung, Yu-Chun Chang, Yan Ding, Kenneth Lim, Qinghua Liu, Langjing Zhu, Wei Zhang, Tzong-Shi Lu, Guerman Molostvov, Daniel Zehnder, Li-Li Hsiao   +10 more
doaj   +1 more source