Sex differences between atherogenic index of plasma and α-klotho levels in middle-aged and older adults: NHANES 2007–2016 [PDF]
Frontiers in EndocrinologyObjectiveKlotho is an anti-aging gene, and the α-klotho protein it encodes reportedly has cardiovascular protective effects. The atherogenic index of plasma (AIP) is a novel and comprehensive lipid index that correlates with atherosclerotic burden and is
Cheng Zuo, Zi-Duo Shen, Yaojun Lu
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Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice [PDF]
Frontiers in Cellular Neuroscience, 2019 The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li +5 more
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The inflection point: α-Klotho levels and the risk of all-cause mortality [PDF]
Frontiers in EndocrinologyPurposeThe controversial nature of the association between α-Klotho and mortality risk in the general population warrants further investigation. This study aims to examine the correlation between circulating α-Klotho levels and the risk of all-cause ...
Jianling Song, Hong Li, Xiangdong Fang
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Sex differences in the association between serum α-Klotho levels and hyperlipidemia: a cross-sectional study from NHANES 2013–2016 [PDF]
Scientific ReportsThis study assessed the association between serum α-Klotho levels and hyperlipidemia. The aim was to ascertain the potential of serum α-Klotho levels as a predictive biomarker for hyperlipidemia.
Yu Han +8 more
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Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults [PDF]
Toxicsα-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear.
Xinliang Zheng +8 more
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Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database [PDF]
Diabetology & Metabolic SyndromeBackground The α-klotho is crucial in diabetes and its related complications. This study seeks to explore the link between α-klotho levels and the risk of diabetic kidney disease (DKD) as well as all-cause and cardiovascular mortality among individuals ...
Yi Kang +7 more
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Association between α-klotho levels and adults with COPD in the United States [PDF]
Frontiers in MedicinePurposeChronic obstructive pulmonary disease (COPD) is accompanied by increased inflammation, persistent lung function decline, and extensive lung injury. Klotho, a well-known antiaging protein, has anti-inflammatory and antioxidative effects.
Dan Yan
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α-klotho reduces susceptibility to osteoarthritis: evidence from cross-sectional studies and Mendelian randomization [PDF]
Frontiers in EndocrinologyBackgroundDespite extensive research, the association between serum α-klotho levels and osteoarthritis (OA) remains unclear, predominantly relying on findings from OA mouse models.
Zhao Li +8 more
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The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample [PDF]
Frontiers in Aging NeuroscienceBackgroundThe Klotho gene is implicated in suppressing aging phenotypes and influencing age-related diseases. Previous studies have delved into its connection with different diseases, yet the association between Klotho and hearing loss has rarely been ...
Siyuan Wang +5 more
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The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007–2012 [PDF]
BMC Endocrine DisordersBackground Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic ...
Jing Dong +5 more
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