Investigation of α-Klotho Concentrations in Serum of Cats Affected by Hypertrophic Cardiomyopathy [PDF]
Veterinary SciencesBeing involved in various physiological and pathophysiological mechanisms (ageing, kidney damage, cardiovascular diseases, etc.), Klotho is a parameter of increasing interest.
Stephan Neumann, Stephan Siegert
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Causal association between circulating α-Klotho levels and venous thromboembolism: a two-sample Mendelian randomization study [PDF]
Thrombosis JournalBackground α-Klotho may involve in the occurrence and development of venous thromboembolism (VTE). However, the underlying relationship between circulating α-Klotho levels and VTE is still unclear.
Yanmin Song, Liping Cao, Hui Long
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Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants [PDF]
Frontiers in Public Health, 2023 PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of ...
Min Li +7 more
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α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells. [PDF]
PLoS ONE, 2017 Endothelial cells (ECs) express fibroblast growth factor (FGF) receptors and are metabolically active after treatment with FGF-23. It is not known if this effect is α-Klotho independent or mediated by humoral or endogenous endothelial α-Klotho.
Chih-Ping Chung +10 more
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Kidney & Blood Pressure Research, 2018 Background/Aims: We aimed to determine if soluble α-klotho level was an indicator of chronic kidney disease (CKD) progression and whether α-klotho interacted with aldosterone during the course of further renal damage.
Jing Qian +7 more
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Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice [PDF]
Frontiers in Cellular Neuroscience, 2019 The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li +5 more
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α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise
Frontiers in Physiology, 2019 α-Klotho, a multifunctional protein, has been demonstrated to protect tissues from injury via anti-oxidation and anti-inflammatory effects. The expression of α-klotho is regulated by several physiological and pathological factors, including acute ...
Zhijian Rao +6 more
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Soluble α-klotho as a novel biomarker in the early stage of nephropathy in patients with type 2 diabetes. [PDF]
PLoS ONE, 2014 OBJECTIVE: Although α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated.
Eun Young Lee +8 more
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Cardiovascular DiabetologyBackground Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events.
Jiao Bi +6 more
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Analytical Cellular Pathology, 2019 Background and Aims. Klotho is an aging-suppressor gene mainly expressed in the renal tubules. The klotho gene encodes the α-klotho protein, which has many functions. Previous studies have found that α-klotho protein has a cardiorenal protective function.
Xi Liu +7 more
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