Results 11 to 20 of about 7,898 (167)

Role of the intracerebroventricular injection α- klotho on food intake in broiler chicken: a novel study [PDF]

Poultry Science
: This novel study investigated the effects of intracerebroventricular (ICV) injection α- klotho and its interaction with neuropeptide Y (NPY) receptors on food intake in broiler chicken.
Tahereh Eslam-aghdam, Shahin Hassanpour, Morteza Zendehdel   +2 more
doaj   +2 more sources

Serum protein α-klotho mediates the association between lead, mercury, and kidney function in middle-aged and elderly populations [PDF]

Environmental Health and Preventive Medicine
Background: Heavy metals are significant risk factors for kidney function. Numerous studies have shown that exposure to heavy metals negatively correlates with kidney function through oxidative stress pathways, and serum α-klotho is linked to oxidative ...
Lin Jiang, Tingting Guo, Xin Zhong, Yini Cai, Wanyu Yang, Jun Zhang   +5 more
doaj   +2 more sources

Involvement of α-klotho in growth hormone (GH) signaling. [PDF]

J Clin Biochem Nutr
Growth hormone (GH) exerts multiple effects on different organs directly or via its main mediator, insulin-like growth factor1 (IGF1). In this study, we focused on the novel relationship between GH action and the antiaging hormone α-klotho ...
Koike M, Sato T, Shiozaki Y, Komiya A, Miura M, Higashi A, Ishikawa A, Takayanagi K, Uga M, Miyamoto KI, Segawa H.   +10 more
europepmc   +3 more sources

Inverted U-shaped relationship between serum vitamin B12 and α-Klotho levels in US adults: a cross-sectional study [PDF]

Frontiers in Nutrition
BackgroundSerum vitamin B12 and α-Klotho are important markers associated with aging. Limited studies have been conducted on the relationship between vitamin B12 and α-Klotho.ObjectivesThis study investigated the relationship between circulating α-Klotho
Yu-shan Li, Xing-ji Gong, Wen-jie Du, Yang Li, Dong-yong He, Jian Yao, Cui Bai   +6 more
doaj   +2 more sources

Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES [PDF]

Tobacco Induced Diseases
Introduction α-Klotho is a circulating protein linked to longevity and healthy aging. While tobacco use is known to reduce α-Klotho levels, the effects of marijuana use on this aging-related biomarker remain unclear.
Kai Wei, Xiaotong Chen
doaj   +2 more sources

Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study [PDF]

Translational Psychiatry
This study examines α-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007–2016) and mortality details from ...
Jiayu Zhao, Tong Zhou, Yang Jing, Jiarui Shao, Cailin Xie, Yingying Huang, Tian Long, Jiaming Luo   +7 more
doaj   +2 more sources

Investigation of α-Klotho Concentrations in Serum of Cats Affected by Hypertrophic Cardiomyopathy [PDF]

Veterinary Sciences
Being involved in various physiological and pathophysiological mechanisms (ageing, kidney damage, cardiovascular diseases, etc.), Klotho is a parameter of increasing interest.
Stephan Neumann, Stephan Siegert
doaj   +2 more sources

Causal association between circulating α-Klotho levels and venous thromboembolism: a two-sample Mendelian randomization study [PDF]

Thrombosis Journal
Background α-Klotho may involve in the occurrence and development of venous thromboembolism (VTE). However, the underlying relationship between circulating α-Klotho levels and VTE is still unclear.
Yanmin Song, Liping Cao, Hui Long
doaj   +2 more sources

Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders

Frontiers in Psychiatry, 2021
Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao, Zuoli Sun, Guangwei Ma, Yuhong Li, Min Liu, Guofu Zhang, Hong Xu, Yane Gao, Jixuan Zhou, Qi Deng, Rena Li, Rena Li   +11 more
doaj   +1 more source

Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice

Molecular Metabolism, 2021
Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry, Peixin Li, Daniel Shookster, Zhiying Jiang, Hongli Li, Brenton Thomas Laing, Wyatt Bunner, Theodore Langton, Qingchun Tong, Hu Huang   +9 more
doaj   +1 more source