Results 31 to 40 of about 7,898 (167)

α-Klotho expressison in human tissue [PDF]

, 2013
Context: α-Klotho has emerged as a powerful regulator of the aging process. To-date, the expression profile of α-Klotho in human tissues is unknown and its existence in some human tissue types is subject to much controversy.
Lim, Kenneth, Groen, Arnoud, Molostvov, Guerman, Lu, Tzongshi, Lilley, Kathryn, Snead, David, James, Sean, Wilkinson, Ian, Ting, Stephen, Hsiao, Li-Li, Hiemstra, Thomas, Zehnder, Daniel   +11 more
core   +1 more source

Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study

Scientific Reports, 2023
Alpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers.
Rui Du, Xiaoyan Tang, Meihua Jiang, Shengli Qian, Li Yang, Xiaoling Tong, Wei Huang   +6 more
doaj   +1 more source

α-Klotho Expression in Human Tissues. [PDF]

, 2015
CONTEXT: α-Klotho has emerged as a powerful regulator of the aging process. To date, the expression profile of α-Klotho in human tissues is unknown, and its existence in some human tissue types is subject to much controversy. OBJECTIVE: This is the first
Groen, Arnoud, Hiemstra, Thomas F, Hsiao, Li-Li, James, Sean, Lilley, Kathryn S, Lim, Kenneth, Lu, Tzongshi, Molostvov, Guerman, Snead, David, Ting, Stephen, Wilkinson, Ian B, Zehnder, Daniel   +11 more
core   +2 more sources

Soluble α-klotho as a novel biomarker in the early stage of nephropathy in patients with type 2 diabetes. [PDF]

PLoS ONE, 2014
OBJECTIVE: Although α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated.
Eun Young Lee, Sang Soo Kim, Ji-Sung Lee, In Joo Kim, Sang Heon Song, Seung-Kuy Cha, Kyu-Sang Park, Jeong Suk Kang, Choon Hee Chung   +8 more
doaj   +1 more source

α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells. [PDF]

PLoS ONE, 2017
Endothelial cells (ECs) express fibroblast growth factor (FGF) receptors and are metabolically active after treatment with FGF-23. It is not known if this effect is α-Klotho independent or mediated by humoral or endogenous endothelial α-Klotho.
Chih-Ping Chung, Yu-Chun Chang, Yan Ding, Kenneth Lim, Qinghua Liu, Langjing Zhu, Wei Zhang, Tzong-Shi Lu, Guerman Molostvov, Daniel Zehnder, Li-Li Hsiao   +10 more
doaj   +1 more source

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects [PDF]

, 2010
Background α-Klotho (αKl) regulates mineral metabolism such as calcium ion (Ca2+) and inorganic phosphate (Pi) in circulation. Defects in mice result in clinical features resembling disorders found in human aging.
Aono, Yukiko, Econs, Michael J., Hasegawa, Hisashi, Hataya, Hiroshi, Ichikawa, Shoji, Imel, Erik A., Imura, Akihiro, Kitaoka, Taichi, Kurumatani, Norio, Murakami, Junko, Nabeshima, Yo-ichi, Nakatani, Kimihiko, Namba, Noriyuki, Okamoto, Nozomi, Ozono, Keiichi, Saito, Yoshihiko, Sakai, Tomoyuki, Shimada, Takashi, Urakawa, Itaru, Yamashita, Takeyoshi, Yamazaki, Yuji   +20 more
core   +1 more source

Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth

BMC Nutrition, 2021
Background Klotho is an anti-aging protein mainly expressed in the kidneys with a smaller amount expressed in adipose tissue. Klotho effects include roles in reducing oxidative stress, insulin signaling, adipogenesis and glucose metabolism.
Sofia Villagomez, Dena B. Dubal, Jessica Hawkins, Dan Wang, Janet M. Wojcicki   +4 more
doaj   +1 more source

Additional file 1: of Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind, randomized controlled trial

, 2019
Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 Checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 122 kb)
Haidari, Fatemeh, Asadi, Maryam, Mohammadi-Asl, Javad, Ahmadi-Angali, Kambiz   +3 more
openaire   +1 more source

A low fractional excretion of Phosphate/Fgf23 ratio is associated with severe abdominal Aortic calcification in stage 3 and 4 kidney disease patients [PDF]

, 2013
Background: Vascular calcification (VC) contributes to high mortality rates in chronic kidney disease (CKD). High serum phosphate and FGF23 levels and impaired phosphaturic response to FGF23 may affect VC.
Craver Hospital, Lourdes, Dusso Rosso, Adriana, Fernández i Giráldez, Elvira, Martínez Alonso, Montserrat, Sarró, Felipe, Valdivielso Revilla, José Manuel   +5 more
core   +1 more source

Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]

, 2019
We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor, Hwangbo, Cheol, Kim, So-Jin, Lee, Patty J, Li, Alfred, Min, Jin-Na, Peng, Tien, Sauler, Maor, Shan, Peiying, Zhang, Xuchen, Zhang, Yi   +10 more
core   +1 more source