Results 31 to 40 of about 741,770 (157)

Biofluids profile of α-Klotho in patients with Parkinson's disease

, 2021
We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels.
Giannella E., Grillo P., Alwardat M., Pieri M., Pisani A., Schirinzi T., Bernardini S., Di Lazzaro G., Biticchi B., Mercuri N. B., Sancesario G. M.   +10 more
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Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study

Scientific Reports, 2023
Alpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers.
Rui Du, Xiaoyan Tang, Meihua Jiang, Shengli Qian, Li Yang, Xiaoling Tong, Wei Huang   +6 more
doaj   +1 more source

Parathyroid hormone and plasma phosphate are predictors of soluble α-klotho levels in adults of European descent [PDF]

, 2019
Context: α-klotho is an integral membrane protein, that serves as a co-receptor for fibroblast growth factor 23 (FGF23) in conjunction with cognate fibroblast growth factor receptors.
Pastor, Johanne, Fuster, Daniel G., Pechere, Antoinette, Pruijm, Menno, Pechère-Bertschi, Antoinette, Fuster, Daniel G, Fiedler, Georg-Martin, Ponte, Belen, Moe, Orson, Guessous, Idris, Vogt, Bruno, Burnier, Michel, Bochud, Murielle, Leichtle, Alexander Benedikt, Ackermann, Daniel, Dhayat, Nasser A, Devuyst, Olivier; https://orcid.org/, Ehret, Georg Benedikt, Devuyst, Olivier, Ehret, Georg, Moe, Orson W, Dhayat, Nasser A., Martin, Pierre-Yves   +22 more
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Correlation α-klotho vs phosphaturia.

, 2023
Scatterplot showing correlation between renal mRNA α-klotho expression and daily urinary excretion of phosphorus (P) in rats fed normal P diet. (TIF)
Ignacio Lopez (527238), Angela Vidal (17468542), Ana I. Raya (3808522), Mariano Rodriguez (527244), Escolastico Aguilera-Tejero (527239), Azahara Espartero (17468539), Carmen Pineda (3166020)   +6 more
core   +1 more source

GWAS META-analysis followed by MENDELIAN randomisation revealed potential control mechanisms for circulating α-klotho levels [PDF]

, 2021
Background: The protein α-Klotho acts as transmembrane the co-receptor for fibroblast growth factor 23 (FGF-23) and is a key regulator of phosphate homeostasis.
Zheng, Jie, Gergei, I, Brandenburg, V, Movérare-Skrtic, S, Krämer, Bernhard K., Smith, GD, Brandenburg, Vincent, März, W, Moverare-Skrtic, S., Mirza-Schreiber, N., Andlauer, Till F. M., Richard, D., März, Winfried, Kraemer, B., Mueller-Myhsok, B., Brandenburg, V., Mirza-Schreiber, Nazanin, Smith, G., Tobias, Jonathan H., Moverare-Skrtic, Sofia, Andlauer, Till F M, Andlauer, Till F.M., Smith, George Davey, Movérare-Skrtic, Sofia,, Krämer, Bernhard K, Tobias, Jonathan H, Richard, Daniel, Richard, D, Tobias, J., Mirza-Schreiber, N, Zheng, J., Gergei, Ingrid, Mueller-Myhsok, Bertram, Voelkl, J, Ohlsson, Claes,, Müller-Myhsok, B, Zheng, J, Maerz, Winfried, Ohlsson, C, Tobias, JH, Davey Smith, George, Voelkl, J., Falk, Louise, Voelkl, Jakob, Müller-Myhsok, Bertram, Kraemer, Bernhard K., Falk, L., Falk, L, Andlauer, T., Gergei, I., Andlauer, TFM, Maerz, W., Ohlsson, Claes, Ohlsson, C., Krämer, BK   +54 more
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O grande papel de Klotho

, 2021
Klotho is a single-pass transmembrane protein consisting of 1012 amino acids and expressed strongly and weakly in proximal and distal tubular renal epithelial cells, respectively. There are four groups of Klotho proteins.
Delgado Troche, Fabiana Verónica
core   +1 more source

Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth

BMC Nutrition, 2021
Background Klotho is an anti-aging protein mainly expressed in the kidneys with a smaller amount expressed in adipose tissue. Klotho effects include roles in reducing oxidative stress, insulin signaling, adipogenesis and glucose metabolism.
Sofia Villagomez, Dena B. Dubal, Jessica Hawkins, Dan Wang, Janet M. Wojcicki   +4 more
doaj   +1 more source

Additional file 1: of Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind, randomized controlled trial

, 2019
Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 Checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 122 kb)
Haidari, Fatemeh, Asadi, Maryam, mohammadi-asl, Javad, Ahmadi-Angali, Kambiz   +3 more
openaire   +1 more source

Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease

Frontiers in Cardiovascular Medicine, 2022
ObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system.
Jun-Peng Xu, Jun-Peng Xu, Jun-Peng Xu, Rui-Xiang Zeng, Rui-Xiang Zeng, Rui-Xiang Zeng, Mu-Hua He, Shan-Shan Lin, Li-Heng Guo, Li-Heng Guo, Min-Zhou Zhang, Min-Zhou Zhang   +11 more
doaj   +1 more source

Data_Sheet_2_Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease.docx

, 2022
ObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system.
Mu-Hua He (12894758), Min-Zhou Zhang (12254201), Rui-Xiang Zeng (12254189), Li-Heng Guo (12894764), Shan-Shan Lin (12894761), Jun-Peng Xu (12254186)   +5 more
core   +1 more source