Results 51 to 60 of about 7,898 (167)

Serum and urinary soluble α-Klotho as markers of kidney and vascular impairment [PDF]

, 2023
This study was designed to investigate the controversy on the potential role of sKlotho as an early biomarker in Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD), to assess whether sKlotho is a reliable marker of kidney α-Klotho, to deepen the ...
Dusso, Adriana S, Et al.,, Martín-Vírgala, Julia   +2 more
core   +5 more sources

α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid

Frontiers in Aging Neuroscience
IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of ...
Jacob Raber, Jacob Raber, Jacob Raber, Jacob Raber, Alexandra Pederson, Emily Bunnell, Nora Mattek, Nora E. Gray, Steven G. Kohama, Alison R. Weiss, Alison R. Weiss, Alison R. Weiss, Joseph F. Quinn, Henryk F. Urbanski, Henryk F. Urbanski, Henryk F. Urbanski   +15 more
doaj   +1 more source

On the relationship between proteinuria and plasma phosphate. [PDF]

, 2017
Albuminuria is strongly associated with renal and cardiovascular outcomes independently of renal function level. However, the pathophysiology of these associations is debated.
Courbebaisse, M., de Seigneux, S., Wilhelm-Bals, A.   +2 more
core   +2 more sources

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Circulating α-Klotho Levels in Relation to Cardiovascular Diseases: A Mendelian Randomization Study

Frontiers in Endocrinology, 2022
BackgroundSeveral studies have reported a protective role of circulating α-Klotho on cardiovascular diseases (CVD); however, the causality remains unclear.
Xingang Sun, Lu Chen, Yuxian He, Liangrong Zheng   +3 more
doaj   +1 more source

Circulating α-Klotho Levels Are Inversely Correlated to FGF-23 in Tumour Induced Osteomalacia [PDF]

, 2013
Tumour induced osteomalacia is characterised by high circulating levels of fibroblast growth factor 23 (FGF23) due to ectopic secretion from mesenchymal tumors.
Fraser, William, Piec, Isabelle, Tang, Jonathan, Washbourne, Christopher, Zeun, Paul   +4 more
core  

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

The Protective Role of Klotho in CKD-Associated Cardiovascular Disease

Kidney Diseases, 2020
Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in advanced CKD. The major pathological changes of CKD-associated CVD are severe vascular media calcification, aberrant cardiac remodeling such as hypertrophy and
Xianjin Bi, Ke Yang, Bo Zhang, Jinghong Zhao   +3 more
doaj   +1 more source

Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture

Scientific Reports, 2022
The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytokines in response
Vinicius Wanatable Nakao, Caio Henrique Yokowama Mazucanti, Larissa de Sá Lima, Paloma Segura de Mello, Natacha Medeiros de Souza Port’s, Paula Fernanda Kinoshita, Jacqueline Alves Leite, Elisa Mitiko Kawamoto, Cristoforo Scavone   +8 more
doaj   +1 more source

The physiology of endocrine systems with ageing [PDF]

, 2018
During ageing, the secretory patterns of the hormones produced by the hypothalamic-pituitary axis change, as does the sensitivity of the axis to negative feedback by end hormones.
Egan, Josephine M, Kaufman, Jean, Lamberts, Steven WJ, van den Beld, Annewieke W, van der Lely, Aart J, Zillikens, M Carola   +5 more
core   +1 more source