Results 61 to 70 of about 7,246 (143)
European Journal of Sport Science, Volume 26, Issue 10, October 2026.ABSTRACT Alcohol craving is a key process in alcohol abuse, especially during young adulthood, a period of heightened vulnerability and continued brain development. Although acute physical exercise has been proposed as a potential strategy to reduce craving and modulate affective and cognitive processes, current evidence remains limited regarding its ...
P. Sampedro‐Piquero +5 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague +3 more
wiley +1 more source
Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions
MedComm, Volume 7, Issue 10, October 2026.Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley +1 more source
Experimental GerontologyBackground: Previous research has identified associations between the body roundness index (BRI), a novel marker of abdominal obesity, and serum α-Klotho levels with osteoarthritis (OA).
Wentian Gao +5 more
doaj +1 more source
Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine
MedComm, Volume 7, Issue 10, October 2026.Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song +4 more
wiley +1 more source
Environmental Health and Preventive MedicineBackground: Heavy metals are significant risk factors for kidney function. Numerous studies have shown that exposure to heavy metals negatively correlates with kidney function through oxidative stress pathways, and serum α-klotho is linked to oxidative ...
Lin Jiang +5 more
doaj +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu +6 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundRecent studies suggest a link between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1), indicating that α-Klotho levels may rise during puberty, including in central precocious puberty (CPP) cases.
Jun-Hong Park, Eu-Seon Noh, Il Tae Hwang
doaj +1 more source
Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
Heliyon, 2019 α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species.
Zhijian Rao +6 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Yixuan Xu +9 more
wiley +1 more source